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. 2014 Jun 2;1(1):ofu028.
doi: 10.1093/ofid/ofu028. eCollection 2014 Mar.

Hypervirulent Klebsiella pneumoniae

Payal K Patel  1 , Thomas A Russo  2 , Adolf W Karchmer  1
Affiliations

Hypervirulent Klebsiella pneumoniae

Payal K Patel et al. Open Forum Infect Dis. .

Abstract

Hypervirulent strains of Klebsiella pneumoniae are associated with abscess formation, commonly hepatic, and metastatic spread, even in healthy patients. We describe a case of this clinical syndrome, genotypic and phenotypic features of the isolate, and briefly review epidemiology, clinical manifestations, and pathogenesis of this underappreciated syndrome.

Keywords: Klebsiella pneumoniae; hypermucoviscous; hypervirulence; virulence factors.

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Figures

Figure 1.
Figure 1.
Magnetic resonance imaging scan performed upon admission demonstrated increased signal at the L1-L3 disc level and in the adjacent vertebral bodies concerning for discitis or osteomyelitis. A large anterior epidural abscess extends down from at least T10. Canal narrowing, which is highlighted, appears to be most severe at L4-L5 from disc bulge and epidural abscess.
See this image and copyright information in PMC

References

    1. Shon AS, Bajwa RP, Russo TA. Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence. 2013;4:1–12. - PMC - PubMed
    1. Russo TA, Olson R, Macdonald U, et al. Aerobactin mediates virulence and accounts for the increased siderophore production under iron limiting conditions by hypervirulent (hypermucoviscous) Klebsiella pneumoniae. Infect Immun. 2014;82:2356–67. - PMC - PubMed
    1. Liu YC, Cheng DL, Lin CL. Klebsiella pneumoniae liver abscess associated with septic endophthalmitis. Arch Intern Med. 1986;146:1913–6. - PubMed
    1. Siu LK, Yeh KM, Lin JC, et al. Klebsiella pneumoniae liver abscess: a new invasive syndrome. Lancet Infect Dis. 2012;12:881–7. - PubMed
    1. Rahimian J, Wilson T, Oram V, et al. Pyogenic liver abscess: recent trends in etiology and mortality. Clin Infect Dis. 2004;39:1654. - PubMed