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Comparative Study
. 1989 Nov 6;185(2):371-81.
doi: 10.1111/j.1432-1033.1989.tb15125.x.

Conformation of two somatostatin analogues in aqueous solution. Study by NMR methods and circular dichroism

C Wynants  1 , D Tourwe, W Kazmierski, V J Hruby, G Van Binst
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Free article
Comparative Study

Conformation of two somatostatin analogues in aqueous solution. Study by NMR methods and circular dichroism

C Wynants et al. Eur J Biochem. .
Free article

Abstract

Cyclic-disulfide-containing analogues of somatostatin, Xaa1-Cys2-Xaa3-DTrp4-Lys6-Thr5-Xaa7- Xaa8 [Xaa1 = H or DPhe; Xaa3 = Phe or Tyr; Xaa7 = Cys, Me2Cys or Me2DCys; Xaa8 = OH, Thr8 (OH) or Thr8NH2], were examined in aqueous solution by 1H-NMR spectroscopy and circular dichroism. The influence of the helical nature of the disulfide bridge and the presence of exocyclic residues on biological activity were investigated with particular care.

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