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. 2015 Nov;23(11):1584-7.
doi: 10.1038/ejhg.2015.11. Epub 2015 Mar 4.

Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease

Ji-In Kim  1 , Jeffrey D Long  1   2 , James A Mills  1 , Nancy Downing  3 , Janet K Williams  3 , Jane S Paulsen  1   4   5 ; PREDICT-HD Investigators and Coordinators of the Huntington Study Group
Collaborators, Affiliations

Performance of the 12-item WHODAS 2.0 in prodromal Huntington disease

Ji-In Kim et al. Eur J Hum Genet. 2015 Nov.

Abstract

The Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition (DSM-5), recommends the World Health Organization Disability Assessment Schedule (WHODAS) 2.0 for routine clinical use. We tested the utility of the 12-item WHODAS 2.0 in prodromal Huntington disease. Using data from 726 participants and 630 companions over a 3-year follow-up, linear mixed models were fitted to test (1) baseline and longitudinal differences by progression group; (2) participant and companion differences within each group; and (3) sensitivity of the 12-item WHODAS in comparison to the 36-item WHODAS and the Total Functional Capacity (TFC) score from the Unified Huntington's Disease Rating Scale. Participants showed baseline group differences whereas companions showed baseline and longitudinal group differences. Companions reported worse functional decline over time than participants as the disease progresses. The 12-item WHODAS detected longitudinal change better than the 36-item WHODAS and the TFC in the medium progression group. Results suggest the 12-item WHODAS 2.0 can detect baseline and longitudinal differences in prodromal HD and may be useful in HD clinical trials.

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Conflict of interest statement

Dr Paulsen and Dr Williams' work has been funded by the National Institutes of Health. Dr Kim, Dr Long, Mr Mills and Dr Downing declare no potential conflicts of interest.

Figures

Figure 1
Figure 1
Fitted linear mixed effects regression curves by group for participant (P) and companion (C) ratings of the 12-item World Health Organization Disability Assessment Schedule (WHODAS) 2.0.
Figure 2
Figure 2
Fitted linear mixed effects regression curves by group for scaled companion 36-item World Health Organization Disability Assessment Schedule (WHODAS) 2.0, companion 12-item WHODAS 2.0, and Total Functional Capacity (TFC) loss scores.
See this image and copyright information in PMC

References

    1. 1Ustun TB, Chatterji S, Kostanjsek N et al: Developing the World Health Organization Disability Assessment Schedule 2.0. Bull World Health Organ 2010; 88: 815–823. - PMC - PubMed
    1. 2Downing NR, Kim JI, Williams JK et al: WHODAS 2.0 in prodromal Huntington disease: measures of functioning in neuropsychiatric disease. Eur J Hum Genet 2014; 22: 958–963. - PMC - PubMed
    1. 3Paulsen JS, Hayden M, Stout JC et al: Preparing for preventive clinical trials: the Predict-HD study. Arch Neurol 2006; 63: 883–890. - PubMed
    1. 4Zhang Y, Long JD, Mills JA, Warner JH, Lu WJ, Paulsen JS: Indexing disease progression at study entry with individuals at-risk for Huntington disease. Am J Med Genet B Neuropsychiatr Genet 2011; 156B: 751–763. - PMC - PubMed
    1. 5Verbeke G, Molenberghs G: Linear mixed models for longitudinal data. New York: Springer, 2000.

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