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. 2015 Sep;34(5):503-507.
doi: 10.1111/dar.12251. Epub 2015 Mar 4.

Gender differences in access to methadone maintenance therapy in a Canadian setting

Paxton Bach  1   2 , M-J Milloy  1   2 , Paul Nguyen  1 , John Koehn  1   2 , Silvia Guillemi  1 , Thomas Kerr  1   2 , Evan Wood  1   2
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Gender differences in access to methadone maintenance therapy in a Canadian setting

Paxton Bach et al. Drug Alcohol Rev. 2015 Sep.

Abstract

Introduction and aims: Methadone maintenance therapy (MMT) is an evidence-based treatment for opioid addiction. While gender differences in MMT pharmacokinetics, drug use patterns and clinical profiles have been previously described, few studies have compared rates of MMT use among community-recruited samples of persons who inject drugs (PWID).

Design and methods: The present study used prospective cohorts of PWID followed between May 1996 and May 2013 in Vancouver, British Columbia, Canada. We investigated potential factors associated with time to methadone initiation using Cox proportional hazards modelling. Stratified analyses were used to examine for gender differences in rates of MMT enrolment.

Results: Overall, 1848 baseline methadone-naïve PWID were included in the study, among whom 595 (32%) were female. In an adjusted model, male gender was independently associated with increased time to MMT initiation and an overall lower rate of enrolment [adjusted relative hazard = 0.74 (95% confidence interval: 0.65-0.85)]. Among both female and male PWID, Caucasian ethnicity and daily injection heroin use were associated with decreased time to methadone initiation, while in females, pregnancy was also associated with more rapid initiation.

Discussion and conclusions: These data highlight gender differences in methadone use among a population of community-recruited PWID. While factors associated with methadone use were similar between genders, rates of use were lower among male PWID, highlighting the need to consider gender when designing strategies to improve recruitment into MMT. [Bach P, Milloy M-J, Nguyen P, Koehn J, Guillemi S, Kerr T, Wood E. Gender differences in access to methadone maintenance therapy in a Canadian setting. Drug Alcohol Rev 2015;34:503-7].

Keywords: MMT opiate substitution treatment; gender; intravenous drug abuse; methadone.

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Figure 1
Figure 1
Cumulative incidence probability curve of time to MMT initiation by gender.
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References

    1. Faggiano F, Vigna-Taglianti F, Versino E, Lemma P. Methadone maintenance at different dosages for opioid dependence. The Cochrane database of systematic reviews. 2003;(3):CD002208. - PubMed
    1. Mattick RP, Breen C, Kimber J, Davoli M. Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence. The Cochrane database of systematic reviews. 2003;(2):CD002209. - PubMed
    1. Chatham LR, Hiller ML, Rowan-Szal GA, Joe GW, Simpson DD. Gender differences at admission and follow-up in a sample of methadone maintenance clients. Substance use & misuse. 1999;34(8):1137–65. - PubMed
    1. Craddock SG, Rounds-Bryant JL, Flynn PM, Hubbard RL. Characteristics and pretreatment behaviors of clients entering drug abuse treatment: 1969 to 1993. The American journal of drug and alcohol abuse. 1997;23(1):43–59. - PubMed
    1. Lin HC, Chang YP, Wang PW, Wu HC, Yen CN, Yeh YC, et al. Gender differences in heroin users receiving methadone maintenance therapy in Taiwan. Journal of addictive diseases. 2013;32(2):140–9. - PubMed