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. 1989 Oct;26(2):91-7.
doi: 10.1016/0198-8859(89)90094-3.

Some disease-associated ancestral haplotypes carry a polymorphism of TNF

R L Dawkins  1 , A Leaver, P U Cameron, E Martin, P H Kay, F T Christiansen
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Some disease-associated ancestral haplotypes carry a polymorphism of TNF

R L Dawkins et al. Hum Immunol. 1989 Oct.

Abstract

We describe here an Nco I restriction fragment length polymorphism of tumor necrosis factor carried by the 8.1 (HLA-A1,B8,BfS,C4AQ0,C4B1,DR3) and the 44.1 (HLA-B44,BfS,C4A3,C4BQ0,DR4) ancestral haplotypes associated with complications of rheumatoid arthritis. By examining multiple examples of these and other ancestral haplotypes it was seen that 8.1 and 44.1 ancestral haplotypes yield fragments of approximately 5.5 kb while many other ancestral haplotypes carry fragments of approximately 10.5 kb. The polymorphism is associated with the ancestral haplotype rather than the HLA-B or -DR allele defined by conventional serology.

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