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Review
. 2015 May 18;21(21):7648-61.
doi: 10.1002/chem.201406432. Epub 2015 Mar 3.

Recent developments in the trifluoromethylation of alkynes

Pin Gao  1 , Xian-Rong Song, Xue-Yuan Liu, Yong-Min Liang
Affiliations
Review

Recent developments in the trifluoromethylation of alkynes

Pin Gao et al. Chemistry. .

Abstract

In the last few years, the development of versatile methodologies to incorporate trifluoromethyl groups into organic molecules has attracted significant attention in synthetic chemistry. This review gives an overview over the development on the trifluoromethylation of alkynes, which have not been solely discussed before. Formation of diverse C(sp, sp(2) , sp(3) )-CF3 bonds are all covered in this review.

Keywords: alkyne; difunctionalization; radical reactions; synthetic methods; trifluoromethylation.

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