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Review
. 2015 Jan;9(1):GE01-6.
doi: 10.7860/JCDR/2015/10443.5394. Epub 2015 Jan 1.

Non viral vectors in gene therapy- an overview

Murali Ramamoorth  1 , Aparna Narvekar  2
Affiliations
Review

Non viral vectors in gene therapy- an overview

Murali Ramamoorth et al. J Clin Diagn Res. 2015 Jan.

Abstract

Non-viral vectors are simple in theory but complex in practice. Apart from intra cellular and extracellular barriers, number of other challenges also needs to be overcome in order to increase the effectiveness of non-viral gene transfer. These barriers are categorized as production, formulation and storage. No one-size-fits-all solution to gene delivery, which is why in spite of various developments in liposome, polymer formulation and optimization, new compounds are constantly being proposed and investigated. In this review, we will see in detail about various types of non-viral vectors highlighting promising development and recent advances that had improved the non-viral gene transfer efficiency of translating from "Bench to bedside".

Keywords: Biological vectors; Engineered vectors; Gene transfer; Transfection.

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Figures

[Table/Fig-1]:
[Table/Fig-1]:
Schematic illustration of key steps in gene therapy
See this image and copyright information in PMC

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