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. 2015 May;25(5):259-62.
doi: 10.1097/FPC.0000000000000133.

A twin study of the trough plasma steady-state concentration of metformin

Tore B Stage  1 , Per Damkier, Rasmus S Pedersen, Mette M H Christensen, Lene Christiansen, Kaare Christensen, Kim Brosen
Affiliations

A twin study of the trough plasma steady-state concentration of metformin

Tore B Stage et al. Pharmacogenet Genomics. 2015 May.

Abstract

Objective: The aim of this study was to determine the intrapair similarity in trough steady-state plasma concentrations of metformin in monozygotic and dizygotic twin pairs.

Methods: We included 16 twin pairs (eight monozygotic and eight dizygotic twin pairs) for this study after contacting 524 twin pairs. They were dosed with metformin to steady state (1 g twice daily) for 6 days and on day 7, the trough concentration of metformin was determined 12 h after the last dose.

Results: There was no strong intrapair similarity in trough steady-state plasma concentrations of metformin in either dizygotic or monozygotic twin pairs.

Conclusion: The trough steady-state plasma concentration of metformin does not appear to be tightly genetically regulated. The interpretation of this finding is limited by the small sample size.

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