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Comment
. 2015 Mar 3;21(3):355-6.
doi: 10.1016/j.cmet.2015.02.013.

A mitochondrially encoded hormone ameliorates obesity and insulin resistance

Kim Zarse  1 , Michael Ristow  2
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A mitochondrially encoded hormone ameliorates obesity and insulin resistance

Kim Zarse et al. Cell Metab. .
Free article

Abstract

MOTS-c, a mitochondrially encoded open reading frame-derived peptide recently discovered by Lee et al. 2015 (this issue of Cell Metabolism) promotes biosynthesis of an endogenous AMP analog, AICAR. As AICAR activates AMPK, the discovery of MOTS-c offers an unexpected therapeutic option to be exploited toward the prevention of type 2 diabetes and delaying of the aging processes.

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