The International Nucleome Consortium
- PMID: 25738524
- PMCID: PMC4615172
- DOI: 10.1080/19491034.2015.1022703
The International Nucleome Consortium
Abstract
The eukaryotic genome adopts in the cell nucleus a 3-dimensional configuration that varies with cell types, developmental stages and environmental condition as well as between normal and pathological states. Understanding genome function will therefore require the elucidation of the structure-function relationship of the cell nucleus as a complex, dynamic biological system, referred to as the nucleome. This exciting and timely task calls for a multi-faceted, interdisciplinary and multi-national effort. We propose the establishment of an International Nucleome Consortium to coordinate this effort worldwide.
Keywords: 4D genome organization; international consortium; nucleome; research themes; scientific collaboration.
References
-
- Cavalli G, Misteli T. Functional implications of genome topology. Nat Struct Mol Biol 2013; 20:290–9; PMID:23463314; http://dx.doi.org/10.1038/nsmb.2474 - DOI - PMC - PubMed
-
- Nora EP, Dekker J, Heard E. Segmental folding of chromosomes: a basis for structural and regulatory chromosomal neighborhoods? Bioessays 2013; 35:818–28; PMID:23832846; http://dx.doi.org/10.1002/bies.201300040 - DOI - PMC - PubMed
-
- Markaki Y, Gunkel M, Schermelleh L, Beichmanis S, Neumann J, Heidemann M, Leonhardt H, Eick D, Cremer C, Cremer T. Functional nuclear organization of transcription and DNA replication: a topographical marriage between chromatin domains and the interchromatin compartment. Cold Spring Harb Symp Quant Biol 2010; 75:475–92; PMID:21467142; http://dx.doi.org/10.1101/sqb.2010.75.042 - DOI - PubMed
-
- Bickmore WA. The spatial organization of the human genome. Annu Rev Genomics Hum Genet 2013; 14:67–84; PMID:23875797; http://dx.doi.org/10.1146/annurev-genom-091212-153515 - DOI - PubMed
-
- Giorgetti L, Galupa R, Nora EP, Piolot T, Lam F, Dekker J, Tiana G, Heard E. Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription. Cell 2014; 157:950–63; PMID:24813616; http://dx.doi.org/10.1016/j.cell.2014.03.025 - DOI - PMC - PubMed
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