Enantioselective direct functionalization of indoles by Pd/sulfoxide-phosphine-catalyzed N-allylic alkylation

Abstract

A general and efficient Pd/sulfoxide-phosphine complex-catalyzed direct asymmetric N-allylic alkylation of indoles has been developed to allow for the preparation of various N-allylated indoles in generally good yields with excellent enantioselectivities. This catalytic system could also be extended to other N-containing heterocycles with good results.