Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Dec 8;246(4935):1298-300.
doi: 10.1126/science.2573953.

A new DNA marker tightly linked to the fragile X locus (FRAXA)

G K Suthers  1 , D F Callen, V J Hyland, H M Kozman, E Baker, H Eyre, P S Harper, S H Roberts, M C Hors-Cayla, K E Davies, et al.
Affiliations

A new DNA marker tightly linked to the fragile X locus (FRAXA)

G K Suthers et al. Science. .

Abstract

The fragile X syndrome is the most common cause of familial mental retardation. Genetic counseling and gene isolation are hampered by a lack of DNA markers close to the disease locus. Two somatic cell hybrids that each contain a human X chromosome with a breakpoint close to the fragile X locus have been characterized. A new DNA marker (DXS296) lies between the chromosome breakpoints and is the closest marker to the fragile X locus yet reported. The Hunter syndrome gene, which causes iduronate sulfatase deficiency, is located at the X chromosome breakpoint that is distal to this new marker, thus localizing the Hunter gene distal to the fragile X locus.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources