Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 May;89(10):5200-3.
doi: 10.1128/JVI.02470-14. Epub 2015 Mar 4.

Exosomal communication goes viral

David G Meckes Jr  1
Affiliations
Review

Exosomal communication goes viral

David G Meckes Jr. J Virol. 2015 May.

Abstract

Exosomes are small vesicles secreted from cells that participate in intercellular communication events. Accumulating evidence demonstrates that host exosome pathways are hijacked by viruses and that virally modified exosomes contribute to virus spread and immune evasion. In the case of tumor viruses, recent findings suggest that alterations in normal exosome biology may promote the development and progression of cancer. These studies will be discussed in the context of our current knowledge of Epstein-Barr virus (EBV)-modified exosomes.

PubMed Disclaimer

Figures

FIG 1
FIG 1
Effects of EBV infection on the components and functions of exosomes. Many proteins have been found to be incorporated at high levels in exosomes released from EBV-infected cells or as a result of LMP1 expression in exosome-producing cells (black text). Other viral and cellular factors that are uniquely packaged into EBV-modified exosomes compared to their packaging in exosomes from control uninfected cells are highlighted in red text. These changes in exosome components due to EBV and the proposed physiological changes in recipient cells following exposure to EBV-modified exosomes are summarized here. ILV, intraluminal vesicles.
See this image and copyright information in PMC

References

    1. Meckes DG, Raab-Traub N. 2011. Microvesicles and viral infection. J Virol 85:12844–12854. doi:10.1128/JVI.05853-11. - DOI - PMC - PubMed
    1. Meckes DG, Gunawardena HP, Dekroon RM, Heaton PR, Edwards RH, Ozgur S, Griffith JD, Damania B, Raab-Traub N. 2013. Modulation of B-cell exosome proteins by gamma herpesvirus infection. Proc Natl Acad Sci U S A 110:E2925–E2933. doi:10.1073/pnas.1303906110. - DOI - PMC - PubMed
    1. Dargan DJ, Subak-Sharpe JH. 1997. The effect of herpes simplex virus type 1 L-particles on virus entry, replication, and the infectivity of naked herpesvirus DNA. Virology 239:378–388. doi:10.1006/viro.1997.8893. - DOI - PubMed
    1. Ramakrishnaiah V, Thumann C, Fofana I, Habersetzer F, Pan Q, de Ruiter PE, Willemsen R, Demmers JAA, Stalin Raj V, Jenster G, Kwekkeboom J, Tilanus HW, Haagmans BL, Baumert TF, van der Laan LJW. 2013. Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells. Proc Natl Acad Sci U S A 110:13109–13113. doi:10.1073/pnas.1221899110. - DOI - PMC - PubMed
    1. Feng Z, Hensley L, McKnight KL, Hu F, Madden V, Ping L, Jeong S-H, Walker C, Lanford RE, Lemon SM. 2013. A pathogenic picornavirus acquires an envelope by hijacking cellular membranes. Nature 496:367–371. doi:10.1038/nature12029. - DOI - PMC - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources