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Case Reports
. 2015 Mar-Apr;16(2):440-3.
doi: 10.3348/kjr.2015.16.2.440. Epub 2015 Feb 27.

Single nodular opacity of granulomatous pneumocystis jirovecii pneumonia in an asymptomatic lymphoma patient

Hyun Soo Kim  1 , Kyung Eun Shin  1 , Ju-Hie Lee  2
Affiliations
Case Reports

Single nodular opacity of granulomatous pneumocystis jirovecii pneumonia in an asymptomatic lymphoma patient

Hyun Soo Kim et al. Korean J Radiol. 2015 Mar-Apr.

Abstract

The radiologic findings of a single nodule from Pneumocystis jirovecii pneumonia (PJP) have been rarely reported. We described a case of granulomatous PJP manifesting as a solitary pulmonary nodule with a halo sign in a 69-year-old woman with diffuse large B cell lymphoma during chemotherapy. The radiologic appearance of the patient suggested an infectious lesion such as angioinvasive pulmonary aspergillosis or lymphoma involvement of the lung; however, clinical manifestations were not compatible with the diseases. The nodule was confirmed as granulomatous PJP by video-assisted thoracoscopic surgery biopsy.

Keywords: Granulomatous Pneumocystis jirovecii pneumonia; Lymphoma; Nodular opacity.

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Figures

Fig. 1
Fig. 1. 69-year-old woman with granulomatous PJP.
Chest CT shows small subpleural nodule in right lower lobe (A) and shows high uptake on PET-CT (B). Follow-up CT taken 10 days later shows progression of nodule with peripheral ground glass opacity (C). Histopathologic features of granulomatous PJP show chronic granulomatous inflammation (white arrows) with foamy exudates (black arrowheads) (D, hematoxylin and eosin stain, × 400) and Pneumocystis cysts (white arrows) (E, Gomori methenamine silver stain, × 400). CT = computed tomography, PET-CT = positron emission tomography-computed tomography, PJP = Pneumocystis jirovecii pneumonia
See this image and copyright information in PMC

References

    1. Boiselle PM, Crans CA, Jr, Kaplan MA. The changing face of Pneumocystis carinii pneumonia in AIDS patients. AJR Am J Roentgenol. 1999;172:1301–1309. - PubMed
    1. Marchiori E, Müller NL, Soares Souza A, Jr, Escuissato DL, Gasparetto EL, Franquet T. Pulmonary disease in patients with AIDS: high-resolution CT and pathologic findings. AJR Am J Roentgenol. 2005;184:757–764. - PubMed
    1. Pastores SM, Garay SM, Naidich DP, Rom WN. Review: pneumothorax in patients with AIDS-related Pneumocystis carinii pneumonia. Am J Med Sci. 1996;312:229–234. - PubMed
    1. Hartz JW, Geisinger KR, Scharyj M, Muss HB. Granulomatous pneumocystosis presenting as a solitary pulmonary nodule. Arch Pathol Lab Med. 1985;109:466–469. - PubMed
    1. Chang H, Shih LY, Wang CW, Chuang WY, Chen CC. Granulomatous Pneumocystis jiroveci pneumonia in a patient with diffuse large B-cell lymphoma: case report and review of the literature. Acta Haematol. 2010;123:30–33. - PubMed

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