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. 2015 Feb 24:7:11.
doi: 10.1186/s13098-015-0004-9. eCollection 2015.

High serum ferritin level is an independent risk factor for metabolic syndrome in a Chinese male cohort population

Qin Tang #  1   2   3 , Zhenfang Liu #  4 , Yan Tang  1   2   3 , Aihua Tan  1   5 , Yong Gao  1 , Zheng Lu  1   6 , Qiuyan Wang  1   2   3 , Yingchun Chen  1   2   3 , Chunlei Wu  1 , Haiying Zhang  1   7 , Xiaobo Yang  1   2   3   7 , Zengnan Mo  1   2   3   6
Affiliations

High serum ferritin level is an independent risk factor for metabolic syndrome in a Chinese male cohort population

Qin Tang et al. Diabetol Metab Syndr. .

Abstract

Background: Elevated serum ferritin levels have been reported to contribute to metabolic syndrome (MetS). We examined the association of serum ferritin levels with the development of MetS in a representative sample of Chinese male adult population.

Method: The data came from the 2009-2013 Fangchenggang Area Males Health and Examination Survey (FAMHES). We combined a cross-sectional study of 2417 males and a longitudinal study of 857 males who participated in the FAMHES.

Result: The serum ferritin level of MetS was higher than that of nonMetS (median and percentiles 25-75: 447.4 (294.1-612.4) vs. 302.4 (215.0-435.8) ng/ml, p < 0.01). A positive correlation between ferritin concentrations and blood pressure (Systolic BP: R = 0.110, Diastolic BP: R = 0.158), waist circumference (R = 0.333), fasting glucose (R = 0.089), triglyceride (R = 0.315) and low high-density lipoprotein cholesterol (R = 0.130) was significant (all p < 0.001). Compared with the level of ferritin in the group with no MetS component, the group with all five MetS components had a higher ferritin level (554.7 (340.1-606.4) vs. 274.2 (198.2-384.4) ng/ml). The odd radio (OR) was higher for MetS in the highest ferritin quartile (OR = 2.29, 95% CI = 1.47-3.54) compared with the lowest ferritin quartile after adjustment for multi-factors. After 4-year follow up, 79 subjects newly diagnosed with MetS in 857 cohort male participants in 2013. Compared with the lowest ferritin quartile, the RR of the highest ferritin quartile was 2.55 (95% CI = 1.30-5.00) after multiple adjustments (p < 0.01).

Conclusion: Our findings confirm that the serum ferritin level is associated with the independent components of MetS, and elevated ferritin level is an independent risk factor for MetS development in the Chinese male population during the 4-year follow-up period.

Keywords: Central obesity; High-density lipoprotein cholesterol; Hypertension; Metabolic syndrome; Serum ferritin; Triglycerides.

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Figures

Figure 1
Figure 1
Distribution of ferritin levels according to the numbers of components of the MetS. The ferritin level had a growing trend when the number of MetS components increased in groups (p < 0.001).The bars represent median, 25th, and 75th percentile of ferritin.
Figure 2
Figure 2
Flow chart for selection of study participants. Based on the inclusion criteria, 2417 male participated in the cross-sectional study and 1009 male participated in the cohort study.
Figure 3
Figure 3
Multiple adjusted odds radio and 95% CI of individual components of MetS according to quartile of ferritin. The OR values increased with increasing quartile group of serum ferritin concentrations in waist circumference, triglycerides, and low HDL (all p < 0.01). The serum ferritin level was associated with MetS components adjusting age, BMI, smoking status, alcohol stake, family history of chronic diseases.
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