A genetic linkage map of 32 loci on human chromosome 10
- PMID: 2574142
- DOI: 10.1016/0888-7543(89)90113-4
A genetic linkage map of 32 loci on human chromosome 10
Abstract
We have constructed a genetic linkage map of human chromosome 10 based on DNA probes that detect 47 restriction fragment length polymorphisms (RFLPs) at 32 different loci. Segregation data were collected on a set of multigenerational families provided by the Centre d'Etude du Polymorphisme Humain and maps were constructed using recently developed multipoint analysis techniques. The length of the sex-averaged map is 178 cM and the sex-specific map lengths are 131 cM in males and 255 cM in females. Recombination is significantly higher in female meioses. The mean distance between loci is 5.6 cM for the sex-averaged map. The genetic map spans the length of the chromosome as judged by physical localization of probes by in situ hybridization techniques and mapping of the probes on human-hamster hybrid cell lines containing all or part of chromosome 10. The informativeness of two loci near the locus responsible for multiple endocrine neoplasia type 2A (MEN-2A) has been increased by isolation of cosmids that reveal additional RFLPs at these loci.
Similar articles
-
Genetic linkage map of 46 DNA markers on human chromosome 16.Proc Natl Acad Sci U S A. 1990 Aug;87(15):5754-8. doi: 10.1073/pnas.87.15.5754. Proc Natl Acad Sci U S A. 1990. PMID: 2377614 Free PMC article.
-
A genetic linkage map of human chromosome 5 with 60 RFLP loci.Genomics. 1991 May;10(1):173-85. doi: 10.1016/0888-7543(91)90498-4. Genomics. 1991. PMID: 1675192
-
A genetic linkage map of 96 loci on the short arm of human chromosome 3.Genomics. 1992 Jun;13(2):275-86. doi: 10.1016/0888-7543(92)90243-l. Genomics. 1992. PMID: 1612588
-
The use of linkage analysis and the Centre d'Etude Polymorphisme Humain (CEPH) panel of DNA in the study of the arginine vasopressin, oxytocin and prodynorphin gene loci.Prog Brain Res. 1992;93:309-17. doi: 10.1016/s0079-6123(08)64581-1. Prog Brain Res. 1992. PMID: 1362280 Review. No abstract available.
-
Recombination within a subclass of restriction fragment length polymorphisms may help link classical and molecular genetics.Genetics. 1988 Nov;120(3):809-18. doi: 10.1093/genetics/120.3.809. Genetics. 1988. PMID: 2906304 Free PMC article. Review.
Cited by
-
Linkage analysis of maturity-onset diabetes of the young (MODY): genetic heterogeneity and nonpenetrance.Am J Hum Genet. 1992 Mar;50(3):607-18. Am J Hum Genet. 1992. PMID: 1539597 Free PMC article.
-
Framework multipoint map of the long arm of human chromosome 4 and telomeric localization of the gene for FSHD.Mamm Genome. 1992;3(3):143-50. doi: 10.1007/BF00352458. Mamm Genome. 1992. PMID: 1352159
-
A clinically homogeneous group of families with facioscapulohumeral (Landouzy-Déjérine) muscular dystrophy: linkage analysis of six autosomes.Am J Hum Genet. 1990 Sep;47(3):376-88. Am J Hum Genet. 1990. PMID: 1975474 Free PMC article.
-
A genetic map of chromosome 20q12-q13.1: multiple highly polymorphic microsatellite and RFLP markers linked to the maturity-onset diabetes of the young (MODY) locus.Am J Hum Genet. 1993 Jan;52(1):110-23. Am J Hum Genet. 1993. PMID: 8094595 Free PMC article.
-
Loss of heterozygosity in malignant gliomas involves at least three distinct regions on chromosome 10.Hum Genet. 1993 Sep;92(2):169-74. doi: 10.1007/BF00219686. Hum Genet. 1993. PMID: 8370584