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. 2015 Jan-Feb;20(1):30-9.
doi: 10.1590/2176-9451.20.1.030-039.int.

An interview with Eiji Tanaka

Eiji Tanaka, Emanuel Braga Rêgo, André Wilson Machado, Clarice Nishio, Matheus Melo Pithon

An interview with Eiji Tanaka

Eiji Tanaka et al. Dental Press J Orthod. 2015 Jan-Feb.
No abstract available

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Figures

Figure 1 -
Figure 1 -. LIPUS (BR Sonic Pro, ITO Corp., Tokyo, Japan) used as preventive therapy for root resorption.
Figure 2 -
Figure 2 -. Schematic illustration of mechanisms of signal transduction pathways enhanced by LIPUS (Low intensity Pulsed Ultrasound). LIPUS may regulate synovial cell metabolism via integrin/FAK/MAPK pathway particularly.
Figure 3 -
Figure 3 -. Schematic illustration of the concept of mandibular condylar cartilage degradation. Functional overloading can facilitate hypoxia in the TMJ and mediate the destructive processes associated with osteoarthrosis as an autocrine factor. VEGF induction in OA-cartilage by functional overloading is linked to activation of HIF-1, leading to hypxia in the joint tissue. Furthermore, VEGF regulates the production of MMPs and TIMPs which are among the effectors of extracellular matrix remodeling. Overloading also causes collapse of joint lubrication as a result of HA degradation by free radicals.
Figure 4 -
Figure 4 -. Local administration of Mst-siRNA/atelocollagen complex causes enlargement of the masseter muscle in mutant caveolin-3 transgenic (mCAV-3Tg) mice, an animal model for muscular dystrophy. A) Photographs of siRNA-treated muscles. The left muscle injected with Mst-siRNA/atelocollagen complex shows a marked increase in muscle mass compared to the right muscle injected with the control siRNA. B) Average muscle weight. The muscle weight of the Mst-siRNAtreated masseter muscle is significantly larger than that of the control muscle. C) Hematoxylin and eosin staining of the control and Mst-siRNA-treated masseter muscles. Scale bars = 50 µm. D) Average cross-sectional areas. The sectional area of fiber is significantly larger in the Mst-siRNA-treated masseter muscle than in the control. E) The ratio of the amount of myostatin mRNA for the masseter muscles. mRNA expression level in the Mst-siRNA-treated masseter muscle is significantly higher than that in the control masseter muscle. Data are expressed as means ± SD. (** P < 0.01, n = 12.).
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References

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