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Comparative Study
. 2015 Apr 28;112(9):1546-8.
doi: 10.1038/bjc.2015.78. Epub 2015 Mar 5.

Age-specific risk of breast cancer in women with neurofibromatosis type 1

O O Seminog  1 , M J Goldacre  1
Affiliations
Comparative Study

Age-specific risk of breast cancer in women with neurofibromatosis type 1

O O Seminog et al. Br J Cancer. .

Abstract

Background: Young women with neurofibromatosis type 1 (NF1) are reported to have a higher risk of breast cancer than others, and this might have implications for screening programmes. Our aim was to calculate this risk.

Methods: An all-England linked data set of hospital admissions and deaths was analysed to determine age-specific rates of breast cancer in women with NF1 and controls.

Results: The age-specific excess risk of breast cancer, comparing the NF1 cohort with the control cohort, was elevated 6.5-fold (95% confidence interval 2.6-13.5) in women aged 30-39 years. There was a 4.4 (2.5-7.0) times higher risk among women aged 40-49.

Conclusions: Women with NF1 develop breast cancer at younger ages than the general population.

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