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Review
. 1989 Dec 2;2(8675):1291-4.
doi: 10.1016/s0140-6736(89)91908-9.

Genomic imprinting in hereditary glomus tumours: evidence for new genetic theory

A G van der Mey  1 , P D Maaswinkel-Mooy, C J Cornelisse, P H Schmidt, J J van de Kamp
Affiliations
Review

Genomic imprinting in hereditary glomus tumours: evidence for new genetic theory

A G van der Mey et al. Lancet. .

Abstract

A study based on fifteen pedigrees showed that familial glomus tumours are inherited almost exclusively via the paternal line, a finding inconsistent with autosomal dominant transmission. The results can be explained in terms of the genomic imprinting hypothesis--the maternally derived gene is inactivated during female oogenesis and can be reactivated only during spermatogenesis. Genomic imprinting may have considerable implications for genetic counselling with respect to glomus tumours and also for the understanding of other hereditary diseases.

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Comment in

  • Inheritance of glomus tumours.
    Hulsebos TJ, Slater RM, Westerveld A. Hulsebos TJ, et al. Lancet. 1990 Mar 17;335(8690):660. doi: 10.1016/0140-6736(90)90446-c. Lancet. 1990. PMID: 1969034 No abstract available.

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