doi: 10.1016/s0140-6736(89)91969-7.
Prenatal sex determination by DNA amplification from maternal peripheral blood
Affiliations
- PMID: 2574306
- DOI: 10.1016/s0140-6736(89)91969-7
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Prenatal sex determination by DNA amplification from maternal peripheral blood
Lancet.
.
Abstract
The polymerase chain reaction was used to amplify a Y-specific repeat sequence in peripheral blood DNA samples from 19 pregnant women who had a gestational age of 9 to 41 weeks. Y-specific sequences were amplified from all 12 women who bore a male fetus but in none of 7 women who bore a female fetus. With stringent precautions against contamination, this technique may assist prenatal diagnosis of sex-linked genetic disorders.
Comment in
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Prenatal sex determination.Lancet. 1990 Feb 3;335(8684):291. doi: 10.1016/0140-6736(90)90109-i. Lancet. 1990. PMID: 1967745 No abstract available.
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Source of contamination in polymerase chain reaction assay.Lancet. 1990 May 19;335(8699):1220. doi: 10.1016/0140-6736(90)92740-9. Lancet. 1990. PMID: 1971059 No abstract available.
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Detection of fetal DNA in maternal blood by PCR.Lancet. 1990 May 19;335(8699):1220-1. doi: 10.1016/0140-6736(90)92741-y. Lancet. 1990. PMID: 1971060 No abstract available.
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