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. 1989 Dec 9;2(8676):1363-5.
doi: 10.1016/s0140-6736(89)91969-7.

Prenatal sex determination by DNA amplification from maternal peripheral blood

Y M Lo  1 , P Patel, J S Wainscoat, M Sampietro, M D Gillmer, K A Fleming
Affiliations

Prenatal sex determination by DNA amplification from maternal peripheral blood

Y M Lo et al. Lancet. .

Abstract

The polymerase chain reaction was used to amplify a Y-specific repeat sequence in peripheral blood DNA samples from 19 pregnant women who had a gestational age of 9 to 41 weeks. Y-specific sequences were amplified from all 12 women who bore a male fetus but in none of 7 women who bore a female fetus. With stringent precautions against contamination, this technique may assist prenatal diagnosis of sex-linked genetic disorders.

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Comment in

  • Prenatal sex determination.
    Nakagome Y, Nagafuchi S, Nakahori Y. Nakagome Y, et al. Lancet. 1990 Feb 3;335(8684):291. doi: 10.1016/0140-6736(90)90109-i. Lancet. 1990. PMID: 1967745 No abstract available.
  • Source of contamination in polymerase chain reaction assay.
    Porter-Jordan K, Garrett CT. Porter-Jordan K, et al. Lancet. 1990 May 19;335(8699):1220. doi: 10.1016/0140-6736(90)92740-9. Lancet. 1990. PMID: 1971059 No abstract available.
  • Detection of fetal DNA in maternal blood by PCR.
    Holzgreve W, Gänshirt-Ahlert D, Burschyk M, Horst J, Miny P, Gal A, Pohlschmidt M. Holzgreve W, et al. Lancet. 1990 May 19;335(8699):1220-1. doi: 10.1016/0140-6736(90)92741-y. Lancet. 1990. PMID: 1971060 No abstract available.

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