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Case Reports
. 2015 Mar 5:2015:bcr2015209365.
doi: 10.1136/bcr-2015-209365.

Healing the orphaned heart: heart failure in a patient with glucose-6-phosphate dehydrogenase deficiency

Percy Guanzon Balderia  1 , Supakanya Wongrakpanich  1 , Monil Patel  1 , Marjorie Stanek  2
Affiliations
Case Reports

Healing the orphaned heart: heart failure in a patient with glucose-6-phosphate dehydrogenase deficiency

Percy Guanzon Balderia et al. BMJ Case Rep. .

Abstract

Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency are not represented in clinical trials for heart failure. Moreover, many of the recommended medications can cause haemolysis in this group of patients. We present the case of a 71-year-old woman with G6PD deficiency admitted for acute non-ischemic heart failure with reduced ejection fraction. Our experience showed that a combination of ethacrynic acid and spironolactone is safe and effective for relief of volume overload in this group of patients. Studies are needed to determine whether the morbidity and mortality benefits of established heart failure regimens extend to patients with G6PD deficiency.

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References

    1. Yancy CW, Jessup M, Bozkurt B, et al. ; American College of Cardiology Foundation; American Heart Association Task Force on Practice Guidelines . 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013;62:e147–239. 10.1016/j.jacc.2013.05.019 - DOI - PubMed
    1. Nkhoma ET, Poole C, Vannappagari V et al. . The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Dis 2009;42:267–78. 10.1016/j.bcmd.2008.12.005 - DOI - PubMed
    1. Luzzatto L, Seneca E. G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications. Br J Haematol 2014;164:469–80. 10.1111/bjh.12665 - DOI - PMC - PubMed
    1. Beutler E, Gaetani G, der Kaloustian V et al. . Glucose-6-phosphate dehydrogenase deficiency. Bull World Health Organ 1989;67:601–11. - PMC - PubMed
    1. Leopold JA, Dam A, Maron BA et al. . Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med 2007;13:189–97. 10.1038/nm1545 - DOI - PMC - PubMed

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