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. 2015 Mar 5;3(2):e00017-15.
doi: 10.1128/genomeA.00017-15.

Draft Genome Sequence of a New Delhi Metallo-β-Lactamase-5 (NDM-5)-Producing Multidrug-Resistant Escherichia coli Isolate

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Draft Genome Sequence of a New Delhi Metallo-β-Lactamase-5 (NDM-5)-Producing Multidrug-Resistant Escherichia coli Isolate

Tom J B de Man et al. Genome Announc. .

Abstract

A multidrug-resistant Escherichia coli isolate from an abdominal lesion displayed resistance to all β-lactams tested, including carbapenems, in addition to macrolides, fluoroquinolones, and tetracycline. Sequence analyses demonstrated the presence of blaNDM-5 in addition to at least 13 genes and 6 efflux pumps associated with antibiotic resistance.

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References

    1. Bush K. 2010. Bench-to-bedside review: the role of β-lactamases in antibiotic-resistant gram-negative infections. Crit Care 14:224–232. doi:10.1186/cc8892. - DOI - PMC - PubMed
    1. Perez F, van Duin D. 2013. Carbapenem-resistant Enterobacteriaceae: a menace to our most vulnerable patients. Cleve Clin J Med 80:225–233. doi:10.3949/ccjm.80a.12182. - DOI - PMC - PubMed
    1. Nordmann P, Cuzon G, Naas T. 2009. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 9:228–236. doi:10.1016/S1473-3099(09)70054-4. - DOI - PubMed
    1. Köser CU, Ellington MJ, Peacock SJ. 2014. Whole-genome sequencing to control antimicrobial resistance. Trends Genet 30:401–407. - PMC - PubMed
    1. Epstein L, Hunter JC, Arwady MA, Tsai V, Stein L, Gribogiannis M, Frias M, Guh AY, Laufer AS, Black S, Pacilli M, Moulton-Meissner H, Rasheed JK, Avillan JJ, Kitchel B, Limbago BM, MacCannell D, Lonsway D, Noble-Wang J, Conway J, Conover C, Vernon M, Kallen AJ. 2014. New Delhi metallo-β-lactamase–producing carbapenem-resistant Escherichia coli associated with exposure to duodenoscopes. JAMA 312:1447–1455. doi:10.1001/jama.2014.12720. - DOI - PMC - PubMed

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