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Meta-Analysis
. 2015 Nov;41(6):1379-86.
doi: 10.1093/schbul/sbv016. Epub 2015 Mar 5.

A Systematic Review of the Effect of Early Interventions for Psychosis on the Usage of Inpatient Services

Jason R Randall  1 , Sherri Vokey  2 , Hal Loewen  2 , Patricia J Martens  1 , Marni Brownell  1 , Alan Katz  1 , Nathan C Nickel  1 , Elaine Burland  3 , Dan Chateau  4
Affiliations
Meta-Analysis

A Systematic Review of the Effect of Early Interventions for Psychosis on the Usage of Inpatient Services

Jason R Randall et al. Schizophr Bull. 2015 Nov.

Abstract

Objectives: To review and synthesize the currently available research on whether early intervention for psychosis programs reduce the use of inpatient services.

Methods: A systematic review was conducted using keywords searches on PubMed, Embase (Ovid), PsycINFO (ProQuest), Scopus, CINAHL (EBSCO), Social Work Abstracts (EBSCO), Social Science Citations Index (Web of Science), Sociological Abstracts (ProQuest), and Child Development & Adolescent Studies (EBSCO). To be included, studies had to be peer-reviewed publications in English, examining early intervention programs using a variant of assertive community treatment, with a control/comparison group, and reporting inpatient service use outcomes. The primary outcome extracted number hospitalized and total N. Secondary outcome extracted means and standard deviations. Data were pooled using random effects models. Primary outcome was the occurrence of any hospitalization during treatment. A secondary outcome was the average bed-days used during treatment period.

Results: Fifteen projects were identified and included in the study. Results of meta-analysis supported the occurrence of a positive effect for intervention for both outcome measures (any hospitalization OR: 0.33; 95% CI 0.18-0.63, bed-days usage SMD: -0.38, 95% CI -0.53 to -0.24). There was significant heterogeneity of effect across the studies. This heterogeneity is due to a handful of studies with unusually positive responses.

Conclusion: These results suggest that early intervention programs are superior to standard of care, with respect to reducing inpatient service usage. Wider use of these programs may prevent the occurrence of admission for patients experiencing the onset of psychotic symptoms.

Keywords: early intervention; health care utilization; psychosis; psychotic disorders; treatment outcome.

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Figures

Fig. 1.
Fig. 1.
PRISMA diagram.
Fig. 2.
Fig. 2.
Meta-analyses for any hospitalization during follow-up period.
Fig. 3.
Fig. 3.
Meta-analysis of inpatient bed-days.
See this image and copyright information in PMC

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References

    1. Casey DA, Rodriguez M, Northcott C, Vickar G, Shihabuddin L. Schizophrenia: medical illness, mortality, and aging. Int J Psychiatry Med. 2011;41:245–251. - PubMed
    1. Saha S, Chant D, McGrath J. A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry. 2007;64:1123–1131. - PubMed
    1. Gray AJ. Stigma in psychiatry. Journal of the Royal Society of Medicine 2002;95:72–76. - PMC - PubMed
    1. Lev-Ran S, Imtiaz S, Rehm J, Le Foll B. Exploring the association between lifetime prevalence of mental illness and transition from substance use to substance use disorders: results from the National Epidemiologic Survey of Alcohol and Related Conditions (NESARC). Am J Addict. 2013;22:93–98. - PubMed
    1. McGorry P. Transition to adulthood: the critical period for pre-emptive, disease-modifying care for schizophrenia and related disorders. Schizophr Bull. 2011;37:524–530. - PMC - PubMed

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