Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2015 Apr;212(4):542.e1-127.
doi: 10.1016/j.ajog.2015.01.021. Epub 2015 Mar 4.

NuMoM2b Sleep-Disordered Breathing study: objectives and methods

Francesca L Facco  1 , Corette B Parker  2 , Uma M Reddy  3 , Robert M Silver  4 , Judette M Louis  5 , Robert C Basner  6 , Judith H Chung  7 , Frank P Schubert  8 , Grace W Pien  9 , Susan Redline  10 , Daniel R Mobley  11 , Matthew A Koch  2 , Hyagriv N Simhan  12 , Chia-Ling Nhan-Chang  13 , Samuel Parry  14 , William A Grobman  15 , David M Haas  8 , Deborah A Wing  7 , Brian M Mercer  5 , George R Saade  16 , Phyllis C Zee  17
Affiliations
Observational Study

NuMoM2b Sleep-Disordered Breathing study: objectives and methods

Francesca L Facco et al. Am J Obstet Gynecol. 2015 Apr.

Abstract

Objective: The objective of the Sleep Disordered Breathing substudy of the Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-be (nuMoM2b) is to determine whether sleep disordered breathing during pregnancy is a risk factor for adverse pregnancy outcomes.

Study design: NuMoM2b is a prospective cohort study of 10,037 nulliparous women with singleton gestations that was conducted across 8 sites with a central Data Coordinating and Analysis Center. The Sleep Disordered Breathing substudy recruited 3702 women from the cohort to undergo objective, overnight in-home assessments of sleep disordered breathing. A standardized level 3 home sleep test was performed between 6(0)-15(0) weeks' gestation (visit 1) and again between 22(0)-31(0) weeks' gestation (visit 3). Scoring of tests was conducted by a central Sleep Reading Center. Participants and their health care providers were notified if test results met "urgent referral" criteria that were based on threshold levels of apnea hypopnea indices, oxygen saturation levels, or electrocardiogram abnormalities but were not notified of test results otherwise. The primary pregnancy outcomes to be analyzed in relation to maternal sleep disordered breathing are preeclampsia, gestational hypertension, gestational diabetes mellitus, fetal growth restriction, and preterm birth.

Results: Objective data were obtained at visit 1 on 3261 women, which was 88.1% of the studies that were attempted and at visit 3 on 2511 women, which was 87.6% of the studies that were attempted. Basic characteristics of the substudy cohort are reported in this methods article.

Conclusion: The substudy was designed to address important questions regarding the relationship of sleep-disordered breathing on the risk of preeclampsia and other outcomes of relevance to maternal and child health.

Keywords: home sleep test; methods; pregnancy; sleep; sleep-disordered breathing.

PubMed Disclaimer

Conflict of interest statement

DISCLOSURE: The authors report no conflict of interest

Figures

Figure 1
Figure 1
Embletta set-up
Figure 2
Figure 2
Examples (from actual study recordings) of sleep disordered breathing events. Each figure representing 2 minutes of recorded sleep. Oxygen desaturations marked in red boxes (Desat) A: Obstructive apnea (Ob. A). B: Central apnea (Cn. A). C. Hypopnea (Hyp).
Figure 2
Figure 2
Examples (from actual study recordings) of sleep disordered breathing events. Each figure representing 2 minutes of recorded sleep. Oxygen desaturations marked in red boxes (Desat) A: Obstructive apnea (Ob. A). B: Central apnea (Cn. A). C. Hypopnea (Hyp).
Figure 2
Figure 2
Examples (from actual study recordings) of sleep disordered breathing events. Each figure representing 2 minutes of recorded sleep. Oxygen desaturations marked in red boxes (Desat) A: Obstructive apnea (Ob. A). B: Central apnea (Cn. A). C. Hypopnea (Hyp).
See this image and copyright information in PMC

References

    1. Berry RB, Budhiraja R, Gottlieb DJ, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med. 2012 Oct 15;8(5):597–619. - PMC - PubMed
    1. Park JG, Ramar K, Olson EJ. Updates on definition, consequences, and management of obstructive sleep apnea. Mayo Clinic proceedings. Mayo Clinic. 2011 Jun;86(6):549–554. quiz 554–545. - PMC - PubMed
    1. Iber C, Ancoli-Israel S, Chesson A, Quan S. The American Academy of Sleep Medicine Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications. 1. Westchester, IL: American Academy of Sleep Medicine; 2007.
    1. Hedman C, Pohjasvaara T, Tolonen U, Suhonen-Malm AS, Myllyla VV. Effects of pregnancy on mothers’ sleep. Sleep Med. 2002 Jan;3(1):37–42. - PubMed
    1. Leung PL, Hui DS, Leung TN, Yuen PM, Lau TK. Sleep disturbances in Chinese pregnant women. Bjog. 2005 Nov;112(11):1568–1571. - PubMed

Publication types