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Review
. 2015 Jul;20(7):906-14.
doi: 10.1016/j.drudis.2015.02.012. Epub 2015 Mar 6.

Urocortin 2 in cardiovascular health and disease

Rui Adão  1 , Diana Santos-Ribeiro  1 , Miriam T Rademaker  2 , Adelino F Leite-Moreira  1 , Carmen Brás-Silva  3
Affiliations
Review

Urocortin 2 in cardiovascular health and disease

Rui Adão et al. Drug Discov Today. 2015 Jul.

Abstract

Urocortin (Ucn)-2 - corticotropin-releasing hormone receptor 2 signaling has favorable effects in the cardiovascular system, including coronary vasodilatation, with increased coronary blood flow and conductance and augmented cardiac contractility and output, as well as protection against ischemia/reperfusion injury. Indeed, several animal studies have confirmed the salutary therapeutic effects of Ucn-2 in chronic heart failure, with improvements in cardiac performance and animal survival. In addition, recent clinical trials have demonstrated the benefits of Ucn-2 in patients with stable chronic heart failure on optimal medical therapy.

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