Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2015 Oct;29(10):2101-4.
doi: 10.1038/leu.2015.67. Epub 2015 Mar 9.

A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone

C N Hahn  1   2   3   4 , D M Ross  3   5   6 , J Feng  7 , A Beligaswatte  5   6 , D K Hiwase  5 , W T Parker  1   2   4 , M Ho  1 , M Zawitkowski  1 , K L Ambler  1 , G D Cheetham  1 , Y K Lee  1 , M Babic  1 , C M Butcher  5 , G A Engler  5 , A L Brown  2   4   5 , R J D'Andrea  2   4   5 , I D Lewis  3   5 , A W Schreiber  7   8 , L B To  3   5 , H S Scott  1   2   3   4   8
Affiliations
Case Reports

A tale of two siblings: two cases of AML arising from a single pre-leukemic DNMT3A mutant clone

C N Hahn et al. Leukemia. 2015 Oct.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Mutational evolution of independent AMLs in two brothers. Mutation profiles of the donor (a) and recipient (b) brothers prior to AML diagnosis, at diagnosis, in remission, and at relapse. (c). Schematic of mutation acquisition and clonal expansion in donor and recipient bone marrow during independent evolution of their AMLs. All previously acquired mutations persisted in diagnosis samples and donor relapse sample. In the donor, all mutations present in the diagnosis sample persisted at relapse. A relapse sample from the recipient was not available. NPM1 detected at *~0.01%. MSC, mesenchymal stromal cells; Dx, diagnosis; CR1, complete remission; Rel, relapse; BMT, bone marrow transplantation; CTx, conditioning chemotherapy.
Figure 2
Figure 2
Persistence of DNMT3A mutations in complete remission. The allelic burden of DNMT3A (R882H/C) mutation was measured using a custom Sequenom assay in serial samples from a cohort of 12 additional patients with DNMT3A-mutant AML, those in whom the mutation was detected during complete remission are shown. Active AML (black), remission (red). Sample types—Dx (diagnosis), CR1 (first complete remission), CR2 (second complete remission), Rel (relapse), P1 (first sample post-BMT), P2 (second sample post-BMT). Numbers along x-axis are time after diagnosis (months).
See this image and copyright information in PMC

References

    1. 1Corces-Zimmerman MR, Hong WJ, Weissman IL, Medeiros BC, Majeti R. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci USA 2014; 111: 2548–2553. - PMC - PubMed
    1. 2Shlush LI, Zandi S, Mitchell A, Chen WC, Brandwein JM, Gupta V et al. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature 2014; 506: 328–333. - PMC - PubMed
    1. 3Hou HA, Kuo YY, Liu CY, Chou WC, Lee MC, Chen CY et al. DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications. Blood 2012; 119: 559–568. - PubMed
    1. 4Fried I, Bodner C, Pichler MM, Lind K, Beham-Schmid C, Quehenberger F et al. Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia. Haematologica 2012; 97: 246–250. - PMC - PubMed
    1. 5Yan XJ, Xu J, Gu ZH, Pan CM, Lu G, Shen Y et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet 2011; 43: 309–315. - PubMed

Substances