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Review
. 1989;20(1):1-65.
doi: 10.1016/s0079-6336(89)80008-7.

Peroxisomal oxidases: cytochemical localization and biological relevance

S Angermüller  1
Affiliations
Review

Peroxisomal oxidases: cytochemical localization and biological relevance

S Angermüller. Prog Histochem Cytochem. 1989.

Abstract

(1) alpha-HAOX has a broad substrate specificity. In rat kidney, the enzyme reacts with aliphatic and aromatic alpha-hydroxy acids, in rat liver, however, only with aliphatic ones. (2) The best substrate for the demonstration of alpha-HAOX activity in rat and human liver is glycolate. (3) alpha-hydroxy butyric acid is the best substrate in the luminometric assay for the demonstration of alpha-HAOX activity in the rat kidney, whereas glycolate is not catalysed by the enzyme. (4) In the proximal tubulus epithelial cells of the rat kidney alpha-HAOX is concentrated in the peripheral matrix of the peroxisomes.

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