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Review
. 2014 Dec;79(13):1635-52.
doi: 10.1134/S0006297914130124.

Human herpes simplex virus: life cycle and development of inhibitors

M K Kukhanova  1 , A N Korovina, S N Kochetkov
Affiliations
Free article
Review

Human herpes simplex virus: life cycle and development of inhibitors

M K Kukhanova et al. Biochemistry (Mosc). 2014 Dec.
Free article

Abstract

WHO reports that 90% of human population is infected by different types of herpesviruses, which develop latency or cause oral and genital herpes, conjunctivitis, eczema herpeticum, and other diseases. Herpesvirus almost always accompanies HIV-infection and complicates AIDS treatment. Herpes simplex virus type 1 is one of the most wide spread viruses from the Herpesviridae family. HSV virion, genome structure, replication mechanisms, antiherpes drug development strategies, including design of prodrugs, and mutations causing ACV-resistance in clinical HSV isolates are discussed in this review.

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