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Review
. 2015 Dec;9(4):447-52.
doi: 10.1007/s12105-015-0622-4. Epub 2015 Mar 8.

Giant Cell Tumor of the Larynx Treated by Surgery and Adjuvant Denosumab: Case Report and Review of the Literature

Aaron E Yancoskie  1 , Douglas K Frank  2 , John E Fantasia  3 , Steven Savona  4 , Nicole Eiseler  5 , Ilan Reder  6 , Leonard B Kahn  6
Affiliations
Review

Giant Cell Tumor of the Larynx Treated by Surgery and Adjuvant Denosumab: Case Report and Review of the Literature

Aaron E Yancoskie et al. Head Neck Pathol. 2015 Dec.

Abstract

Giant cell tumor of the larynx (GCTL) is a rare entity; only 34 cases have been reported in the literature. We report a case of GCTL in a 46 year-old male presenting clinical, radiographic, histological and therapeutic features. Previously reported cases are also reviewed.

Keywords: Denosumab; Giant cell; Head and neck surgery; Larynx.

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Figures

Fig. 1
Fig. 1
Computed tomography scan demonstrating an expansile destructive lesion epicentered on the left thyroid ala with invasion of the overlying strap muscles and involvement of the left glottic and supraglottic tissues
Fig. 2
Fig. 2
Histopathology hematoxcylin and eosin ×200 original magnification. Core biopsy specimen showing giant cells, a mononuclear population and extravasated erythrocytes
Fig. 3
Fig. 3
Gross specimen. Nodular mass measuring 4.5 × 4.0 × 3.5 cm composed of white-tan homogenous, rubbery tissue with a central hemorrhagic focus
Fig. 4
Fig. 4
Histopathology hematoxcylin and eosin ×400 original magnification. Resection specimen demonstrating numerous uniformly distributed osteoclast-like giant cells separated by mononuclear cells in a vascular stroma
See this image and copyright information in PMC

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