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. 1989 Dec:70 ( Pt 12):3327-33.
doi: 10.1099/0022-1317-70-12-3327.

Evaluation of human and simian immunodeficiency virus plaque and neutralization assays

J A McKeating  1 , A McKnight, K McIntosh, P R Clapham, C Mulder, R A Weiss
Affiliations

Evaluation of human and simian immunodeficiency virus plaque and neutralization assays

J A McKeating et al. J Gen Virol. 1989 Dec.

Abstract

A number of CD4+ T cell lines were compared for their ability to act as target cells for human immunodeficiency virus (HIV) infection in syncytium- and plaque-forming assays. MT-4 and C8166 cells were the most sensitive indicator cells for HIV- and simian immunodeficiency virus (SIV)-induced cytopathic effects, and gave rise to macroscopic (MT-4) and microscopic (C8166) plaques. The MT-4 plaque assay was evaluated for the measurement of HIV- and SIV-neutralizing antibodies.

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