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. 2015 Jun;45(8):1731-40.
doi: 10.1017/S0033291714002852. Epub 2015 Mar 10.

Prefrontal hypoactivation during working memory in bipolar II depression

J O Brooks 3rd  1 , N Vizueta  1 , C Penfold  1 , J D Townsend  1 , S Y Bookheimer  1 , L L Altshuler  1
Affiliations

Prefrontal hypoactivation during working memory in bipolar II depression

J O Brooks 3rd et al. Psychol Med. 2015 Jun.

Abstract

Background: Patterns of abnormal neural activation have been observed during working memory tasks in bipolar I depression, yet the neural changes associated with bipolar II depression have yet to be explored.

Method: An n-back working memory task was administered during a 3T functional magnetic resonance imaging scan in age- and gender-matched groups of 19 unmedicated, bipolar II depressed subjects and 19 healthy comparison subjects. Whole-brain and region-of-interest analyses were performed to determine regions of differential activation across memory-load conditions (0-, 1- and 2-back).

Results: Accuracy for all subjects decreased with higher memory load, but there was no significant group × memory load interaction. Random-effects analyses of memory load indicated that subjects with bipolar II depression exhibited significantly less activation than healthy subjects in left hemispheric regions of the middle frontal gyrus [Brodmann area (BA) 11], superior frontal gyrus (BA 10), inferior parietal lobule (BA 40), middle temporal gyrus (BA 39) and bilateral occipital regions. There was no evidence of differential activation related to increasing memory load in the dorsolateral prefrontal or anterior cingulate cortex.

Conclusions: Bipolar II depression is associated with hypoactivation of the left medio-frontal and parietal cortex during working memory performance. Our findings suggest that bipolar II depression is associated with disruption of the fronto-parietal circuit that is engaged in working memory tasks, which is a finding reported across bipolar subtypes and mood states.

Keywords: working memory.

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Conflict of interest statement

Declaration of Interest J.O.B. is on the speakers’ bureau for Sunovion and has received research funding from Pfizer. L.L.A. has received past funding from Takeda Pharmaceuticals North America, Inc., and H. Lundbeck A/S (advisory board honoraria, October 2012), and past and potential future funding from Sunovion Pharmaceuticals Inc. (advisory board honoraria, January 2013). The remaining authors report no financial relationships with commercial interests.

Figures

Fig. 1
Fig. 1
Regions of significant within-group activation in healthy comparison subjects and depressed subjects with bipolar II disorder across 0-, 1- and 2-back conditions. Maps are thresholded at Z > 2.0, p < 0.05 with correction for multiple comparisons.
Fig. 2
Fig. 2
Regions of significantly decreased activation in bipolar II disorder patients relative to healthy comparison subjects across 0-, 1- and 2-back conditions. Maps are thresholded at Z > 2.0, p < 0.05 with correction for multiple comparisons.
See this image and copyright information in PMC

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