Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015;25(4):281-8.
doi: 10.2188/jea.JE20140136. Epub 2015 Mar 7.

Subsequent risk of metabolic syndrome in women with a history of preeclampsia: data from the Health Examinees Study

Jae Jeong Yang  1 , Sang-Ah Lee, Ji-Yeob Choi, Minkyo Song, Sohee Han, Hyung-Suk Yoon, Yunhee Lee, Juhwan Oh, Jong-Koo Lee, Daehee Kang
Affiliations

Subsequent risk of metabolic syndrome in women with a history of preeclampsia: data from the Health Examinees Study

Jae Jeong Yang et al. J Epidemiol. 2015.

Abstract

Background: To investigate whether preeclampsia is independently associated with risk of future metabolic syndrome and whether any such primary associations are modified by different ages at first pregnancy.

Methods: Based on the Health Examinees Study, a cross-sectional analysis was conducted. Data of women (n = 49 780) who had experienced at least 1 pregnancy during their lifetime and had never been diagnosed with any metabolic disorder before their pregnancy were analyzed using multiple logistic regression models. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated after adjusting for age, lifestyle characteristics, and reproductive factors. A stratified analysis was also conducted to estimate the extent of the primary association between preeclampsia and future metabolic syndrome by age at first pregnancy.

Results: Women with a history of preeclampsia had significantly increased odds of developing metabolic syndrome (adjusted OR 1.23; 95% CI, 1.12-1.35), central obesity (adjusted OR 1.36; 95% CI, 1.25-1.47), elevated blood pressure (adjusted OR 1.53; 95% CI, 1.41-1.67), or elevated fasting glucose (adjusted OR 1.13; 95% CI, 1.03-1.25) in later life. In the stratified analysis, women who first became pregnant at ages >35 years and had preeclampsia were found to be at significantly increased likelihood of metabolic syndrome later in life (adjusted OR 4.38; 95% CI, 1.62-11.9).

Conclusions: Our findings suggest that preeclampsia increases the risk of metabolic syndrome in later life, and late age at first pregnancy can further exacerbate this risk.

PubMed Disclaimer

References

    1. Hutcheon JA, Lisonkova S, Joseph KS. Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Best Pract Res Clin Obstet Gynaecol. 2011;25:391–403. 10.1016/j.bpobgyn.2011.01.006 - DOI - PubMed
    1. Hernández-Díaz S, Toh S, Cnattingius S. Risk of pre-eclampsia in first and subsequent pregnancies: prospective cohort study. BMJ. 2009;338:b2255. 10.1136/bmj.b2255 - DOI - PMC - PubMed
    1. Wilson BJ, Watson MS, Prescott GJ, Sunderland S, Campbell DM, Hannaford P, et al. . Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study. BMJ. 2003;326:845. 10.1136/bmj.326.7394.845 - DOI - PMC - PubMed
    1. Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;365:785–99. 10.1016/S0140-6736(05)17987-2 - DOI - PubMed
    1. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 2000;183:S1–22. 10.1067/mob.2000.107928 - DOI - PubMed

Publication types