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Case Reports
. 2015 Jun;40(3):339-41.
doi: 10.1111/jcpt.12255. Epub 2015 Mar 6.

Initial experience of use of tolvaptan in critically ill patients with fluid overload

J Ruiz-Ramos  1 , M Gordon, M A Cortes, M J Broch, P Ramirez
Affiliations
Case Reports

Initial experience of use of tolvaptan in critically ill patients with fluid overload

J Ruiz-Ramos et al. J Clin Pharm Ther. 2015 Jun.

Abstract

What is known and objective: Positive volume balance is related with high mortality in critically ill patients. We describe our experience in the use of tolvaptan in patients with fluid overload.

Case summary: Six patients in the recovery phase from septic shock were included. All patients achieved an increase in diuresis after the first day, with a median fluid balance variation of -2362 (-485 to -3447) mL. At the end of treatment, median fluid balance variation was -9080 (-26,784 to -4395) mL.

What is new and conclusion: Tolvaptan could be an option in critically ill patients with fluid overload and resistant or not treatable with conventional diuretics.

Keywords: clinical pharmacy; drug utilisation; furosemide.

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