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. 2015 Mar 20;17(6):1545-8.
doi: 10.1021/acs.orglett.5b00432. Epub 2015 Mar 10.

Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity

Carolyn A Brotherton  1 , Matthew Wilson  1 , Gary Byrd  2 , Emily P Balskus  1
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Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity

Carolyn A Brotherton et al. Org Lett. .

Erratum in

Abstract

Colibactin is a structurally uncharacterized, genotoxic natural product produced by commensal and pathogenic strains of E. coli that harbor the pks island. A new metabolite has been isolated from a pks(+) E. coli mutant missing an essential biosynthetic enzyme. The unusual azaspiro[2.4] bicyclic ring system of this molecule provides new insights into colibactin biosynthesis and suggests a mechanism through which colibactin and other pks-derived metabolites may exert genotoxicity.

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