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. 2015 Feb;17(2):463.
doi: 10.1007/s11908-015-0463-z.

What Role Does Mycobacterium avium subsp. paratuberculosis Play in Crohn's Disease?

Horacio Bach  1
Affiliations

What Role Does Mycobacterium avium subsp. paratuberculosis Play in Crohn's Disease?

Horacio Bach. Curr Infect Dis Rep. 2015 Feb.

Abstract

Crohn's disease (CD) is a chronic, debilitating inflammatory bowel disease with no etiological agent yet identified. Studies have demonstrated that the bacterium Mycobacterium avium subsp. paratuberculosis (MAP) is present in a high percentage of CD patients. Although MAP has been isolated from human specimens, current techniques fail to show the presence of MAP in 100 % of tissues or biopsies obtained from CD patient lesions, and thus MAP cannot meet Koch's postulate as the etiological agent of CD. In this report, the effect of genetic and immune factors as well as the presence of MAP as a potential environmental factor is analyzed.

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