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Review
. 2015 Jul;62(7):1144-8.
doi: 10.1002/pbc.25462. Epub 2015 Mar 8.

CD19: A multifunctional immunological target molecule and its implications for Blineage acute lymphoblastic leukemia

Judith Weiland  1   2 , Alex Elder  1 , Victoria Forster  1 , Olaf Heidenreich  1 , Steffen Koschmieder  3 , Josef Vormoor  1   4
Affiliations
Review

CD19: A multifunctional immunological target molecule and its implications for Blineage acute lymphoblastic leukemia

Judith Weiland et al. Pediatr Blood Cancer. 2015 Jul.

Abstract

Over the last 20-30 years CD19 has gained attention as a potential target in the therapy of B-cell malignancies. In particular, targeting CD19 with the bispecific T-cell engager (BiTE) antibody Blinatumomab and T-cells modified by chimeric antigen receptors (CAR) has shown promising efficacy in early phase clinical trials for adults and children with precursor B-cell ALL (BCP-ALL). This review will discuss the rationale behind targeting CD19 in BCP-ALL and its potential importance in BCP-ALL signaling pathways.

Keywords: BCP-ALL; CD19; blinatumomab; childhood leukemia; pre-BCR.

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