Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jun;1(1):41-4.
doi: 10.1016/S0973-6883(11)60116-3. Epub 2011 Aug 26.

Association between Celiac Disease and Chronic Hepatitis C Virus Infection

Ashish Garg  1 , Chandrasekhar Reddy  1 , Ajay Duseja  1 , Yogesh Chawla  1 , Radha K Dhiman  1
Affiliations

Association between Celiac Disease and Chronic Hepatitis C Virus Infection

Ashish Garg et al. J Clin Exp Hepatol. 2011 Jun.

Abstract

Celiac disease affects the proximal small intestine and is caused by a local immune response to dietary gluten. Celiac disease usually presents with chronic diarrhea; however, presentations with elevated hepatic transaminase levels in blood or with iron-deficiency anemia have been described. Celiac disease has been reported to be associated with autoimmune liver diseases. Hepatitis C virus (HCV) can also initiate autoimmune disease process. Therefore, HCV infection and celiac disease may occur together. Here, we describe 4 cases of celiac disease associated with chronic hepatitis C. This small case series indicates that chronic HCV infection and celiac disease are not causally associated.

Keywords: AEA, anti-endomysial antibodies; AGA, antigliadin antibodies; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Autoimmune disease; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; HLA, human leukocyte antigen; Ig, immunoglobulin; RNA, ribonucleic acid; WBC, white blood cell; celiac disease; hepatitis C virus infection.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Farrell RJ, Kelly CP. Celiac disease. N Engl J Med. 2002;346:180–188. - PubMed
    1. Novacek G, Miehsler W, Wrba F, Ferenci P, Penner E, Vogelsang H. Prevalence and clinical importance of hypertransaminasaemia in coeliac disease. Eur J Gastroenterol Hepatol. 1999;11:283–288. - PubMed
    1. Yenerel MN, Kalayoglu-Besisik S. Iron deficiency anemia of unknown etiology and/or resistance to the treatment: the sole manifestation of adult celiac disease. Am J Hematol. 1999;61:156–157. - PubMed
    1. Ishak K, Baptista A, Bianchi L. Histological grading and staging of chronic hepatitis. J Hepatol. 1995;22:696–699. - PubMed
    1. Lindgren S, Sjoberg K, Eriksson S. Unsuspected coeliac disease in chronic “cryptogenic” liver disease. Scan J Gastroenterol. 1994;29:661–664. - PubMed