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. 2011 Jun;1(1):41-4.
doi: 10.1016/S0973-6883(11)60116-3. Epub 2011 Aug 26.

Association between Celiac Disease and Chronic Hepatitis C Virus Infection

Ashish Garg  1 , Chandrasekhar Reddy  1 , Ajay Duseja  1 , Yogesh Chawla  1 , Radha K Dhiman  1
Affiliations

Association between Celiac Disease and Chronic Hepatitis C Virus Infection

Ashish Garg et al. J Clin Exp Hepatol. 2011 Jun.

Abstract

Celiac disease affects the proximal small intestine and is caused by a local immune response to dietary gluten. Celiac disease usually presents with chronic diarrhea; however, presentations with elevated hepatic transaminase levels in blood or with iron-deficiency anemia have been described. Celiac disease has been reported to be associated with autoimmune liver diseases. Hepatitis C virus (HCV) can also initiate autoimmune disease process. Therefore, HCV infection and celiac disease may occur together. Here, we describe 4 cases of celiac disease associated with chronic hepatitis C. This small case series indicates that chronic HCV infection and celiac disease are not causally associated.

Keywords: AEA, anti-endomysial antibodies; AGA, antigliadin antibodies; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Autoimmune disease; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; HLA, human leukocyte antigen; Ig, immunoglobulin; RNA, ribonucleic acid; WBC, white blood cell; celiac disease; hepatitis C virus infection.

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