Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan 1;8(1):751-7.
eCollection 2015.

Elevated Aurora B expression contributes to chemoresistance and poor prognosis in breast cancer

Yiqian Zhang  1 , Chunling Jiang  2 , Huilan Li  1 , Feng Lv  1 , Xiaoyan Li  1 , Xiaolong Qian  1 , Li Fu  1 , Bo Xu  2 , Xiaojing Guo  1
Affiliations

Elevated Aurora B expression contributes to chemoresistance and poor prognosis in breast cancer

Yiqian Zhang et al. Int J Clin Exp Pathol. .

Abstract

Aurora-B is a major kinase responsible for appropriate mitotic progression. Elevated expression of Aurora-B has been frequently associated with several types of cancer, including breast cancer. However, it is not clear whether the alteration contributes to tumor responses to therapies and prognosis. In this study, we conducted immunohistochemistry using antibodies against Aurora-B, S1981p-ATM, Ki67, and p53 in paraffin-embedded tumor tissues from 312 invasive breast cancer patients. The correlation between disease-free-survival (DFS) and Aurora-B expression was analyzed using the Kaplan-Meier method and log-rank test. A Cox proportional hazards regression analysis was used to determine whether Aurora-B was an independent prognostic factor for breast cancer. We found that Aurora-B expression was correlated with the proliferation index (P < 0.001) and p53 expression (P = 0.014) in breast cancer tissues. Further we found that Aurora-B expression was associated with lymph node metastasis (P = 0.002) and histological grade (P = 0.001). Multivariate analyses indicated that elevated Aurora-B expression predicted a poor survival. In a subgroup of patients that received neoadjuvant chemotherapy, we found that elevated Aurora-B contributed to chemoresistance (P = 0.011). In conclusion, elevated Aurora-B expression in breast cancer patients contributes to chemoresistance and predicts poor prognosis.

Keywords: Aurora-B; breast cancer; chemoresistance; prognosis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Immunohistochemical study revealing representative images of invasive breast cancer and normal breast tissues with antibody of Aurora-B, nuclei with fine granular staining were counted, and (-/+) was < 5% of the cells stained, (++) was 5-10% of the cells stained, and (+++) was > 10% of the cells stained (A); and representative images of invasive breast cancer tissues stained with antibodies of Ki67, p53 and ATM-S1981p, they were scored as (-) = no positive cells, (+) = 1-10% of the cells stained, (++) = 11-50% of the cells stained, and (+++) = 51-100% of the cells stained as described previously [13] (B).
Figure 2
Figure 2
Kaplan-Meier survival curves of the 312 breast cancer patients with different expression levels of Aurora-B. Kaplan-Meier survival curves showed that higher expression of Aurora-B significantly correlated with the poor survival in these cases (P = 0.038).
See this image and copyright information in PMC

References

    1. Carmena M, Earnshaw WC. The cellular geography of aurora kinases. Nat Rev Mol Cell Biol. 2003;4:842–54. - PubMed
    1. Crosio C, Fimia GM, Loury R, Kimura M, Okano Y, Zhou H, Sen S, Allis CD, Sassone-Corsi P. Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol. 2002;22:874–85. - PMC - PubMed
    1. Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, Guma S, Phan L, Chou PC, Su CH, Zhang F, Chen JS, Yang TY, Yeung SC, Lee MH. Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A. 2012;109:E1513–22. - PMC - PubMed
    1. Yang C, Tang X, Guo X, Niikura Y, Kitagawa K, Cui K, Wong ST, Fu L, Xu B. Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint. Mol Cell. 2011;44:597–608. - PMC - PubMed
    1. Yang C, Wang H, Xu Y, Brinkman KL, Ishiyama H, Wong ST, Xu B. The kinetochore protein Bub1 participates in the DNA damage response. DNA Repair (Amst) 2012;11:185–91. - PMC - PubMed

Publication types