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. 2015 Jan 1;8(1):856-61.
eCollection 2015.

Up-regulation of ROR2 is associated with unfavorable prognosis and tumor progression in cervical cancer

Bo Sun  1 , Xiufeng Ye  1 , Li Lin  1 , Mei Shen  2 , Taotao Jiang  2
Affiliations

Up-regulation of ROR2 is associated with unfavorable prognosis and tumor progression in cervical cancer

Bo Sun et al. Int J Clin Exp Pathol. .

Abstract

Aims: To investigate the clinical significance of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in cervical cancer.

Methods: We examined ROR2 levels in 8 pairs of surgically resected cervical cancer and adjacent normal cervical tissues by real-time PCR. Moreover, we performed immunohistochemistry to examine ROR2 expression in 94 paraffin-embedded cervical cancer samples and analyzed the association between ROR2 expression, clinicopathologic factors and prognosis.

Results: ROR2 expression was up-regulated in cervical cancer tissues compared with adjacent normal cervix. In paraffin-embedded cervical cancer samples, high expression of ROR2 was shown in 40 (42.6%) of 94 cases, also, it was significantly associated with tumor stage (P = 0.018) and lymph nodes metastasis (P = 0.013). Moreover, survival analysis showed that ROR2 expression was an independent prognostic factor of poor overall and recurrent free survival (P = 0.045 and 0.001, respectively).

Conclusion: These results indicate that ROR2 is significantly correlated with cancer progression and poor prognosis in cervical cancer.

Keywords: Cervical cancer; ROR2; prognosis; progression.

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Figures

Figure 1
Figure 1
The ROR2 expression in cervical cancer specimens was detected by Real-time PCR (n = 8) compared with matched adjacent normal tissues. Asterisks, P < 0.05.
Figure 2
Figure 2
High (A) and low (B) expression of ROR2 in cervical cancer tissues by immunohistochemistry (400 × magnification).
Figure 3
Figure 3
Survival analysis of ROR2. Patients with higher ROR2 expression in cervical cancer were closely correlated with poorer overall and recurrent free survival than patients with tumor with lower ROR2 expression.
See this image and copyright information in PMC

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