Angel of human health: current research updates in toad medicine

Abstract

There are currently 34 genera and 410 species of toads in the world. The medicinal parts of toads mainly include their venom, skin, and clothing. The toad's venom and skin possess the same chemical components, mainly the toad venom lactone class, and their pharmacological effects primarily include the maintenance of strong heart, antitumor, antivirus, anti-infection, and analgesic effects. So far, the produces from the medicinal raw materials of the toad are widely used clinically around the world, especially in China, Japan, and South Korea. About 50 varieties of medicines are used in the clinical treatment of various complicated diseases in China, such as "Liushen pills" which was popular in the whole world. Toads are mainly used in treating malignant tumors (e.g., liver cancer, gastric cancer, esophageal cancer, colon cancer, cervical cancer, among others), and some major diseases such as hepatitis B. Despite the therapeutic effects of toad-derived medicines on human health, there is insufficient research and development of toad-derived medicines by leading drug companies. In order to harness the beneficial effects of the resources of the toad species, it is the responsibility of global pharmaceutical researchers to develop and generate economically feasible toad-derived therapeutic products, while promoting maximum protection to the resources of the toad species.

Keywords: Toad; cancer; hepatitis B.

Figure 1

Structure of main chemical ingredients in the toad venom. A. Cinobufagin (CB). B. Resibufogenin (RBG). C. Bufalin (BL). D. Cinobufotalin (CBTL). E. Bufotenine (BT). F. Bufotenidine (BTD). G. Bufobutanoicacid; H. Serotonin. I. Bufotenine N-oxide. J. N-methyl serotonin.

Figure 2

Chemical construction of Bufotaline.

Figure 3

Toad alkadiene acid lactone compounds. A-C. Showed kinds of the mother structures.

Figure 4

The class indole alkaloids. A. Toad thiamethoxam nowadays. B. Sterol compounds. C. Chemical structure of the mother structures.

Figure 5

Toad ring amide compounds structures. A. Bufogargarizaine B. B. Bufogargarizaine D. C. Bufogargarizaine C. D. Telocinobufagin. E. Desacetylcinobufotalin. F. Hellebrigenin.