Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Oct;80(10):920-3.
doi: 10.1111/j.1349-7006.1989.tb01626.x.

Co-amplification of c-myc and c-erbB-2 oncogenes in a poorly differentiated human gastric cancer

T Tsuchiya  1 , Y Ueyama, N Tamaoki, S Yamaguchi, M Shibuya
Affiliations

Co-amplification of c-myc and c-erbB-2 oncogenes in a poorly differentiated human gastric cancer

T Tsuchiya et al. Jpn J Cancer Res. 1989 Oct.

Abstract

c-erbB-2 oncogene has been reported to be frequently amplified in differentiated, tubular type of gastric cancer. Here we report a human gastric cancer which bore co-amplified c-myc and c-erbB-2 oncogenes: a portion of the amplified c-erbB-2 oncogene was found to be rearranged. Furthermore, c-myc and c-erbB-2 oncogenes were over-expressed in the tumor cells. In contrast to the previous reports, this gastric adenocarcinoma was classified as a poorly differentiated type, and was highly tumorigenic in nude mice. These results might suggest that activated c-myc and c-erbB-2 oncogenes co-operate and influence the malignant state of some gastric carcinomas.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. ) Reddy , E. P. , Reynolds , R. K. , Santos , E. and Barbacid , M.A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene . Nature , 300 , 149 – 152 ( 1982. ). - PubMed
    1. ) Tahiti , C.J. , Bradley , S. M. , Bargmann , C. I. , Weinberg , R. A. , Papageorge , A. G. , Scolnick , E. M. , Dhar , R. , Lowy , D. R. and Chang , E. H.Mechanism of activation of a human oncogene . Nature , 300 , 143 – 149 ( 1982. ). - PubMed
    1. ) Taub , R. , Kirsch , I. , Morton , C. , Lenoir , G. , Swan , D. , Tronick , S. , Aaronson , S. and Leder , P.Translocation of the c‐myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells . Proc. Natl Acad. Set USA , 79 , 7837 – 7841 ( 1982. ). - PMC - PubMed
    1. ) Alitalo , K. , Schwab , M. , Lin , C. C. , Varmus , H. E. and Bishop , J. M.Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c‐myc) in colon carcinoma . Proc. Natl, Acad. Sci. USA , 80 , 1707 – 1711 ( 1983. ). - PMC - PubMed
    1. ) Collins , S , and Groudine , M.Amplification of endogenous myc‐related DNA sequences in a human myeloid leukemia cell line . Nature , 298 , 679 – 681 ( 1982. ). - PubMed

Publication types