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. 1989 Oct;80(10):920-3.
doi: 10.1111/j.1349-7006.1989.tb01626.x.

Co-amplification of c-myc and c-erbB-2 oncogenes in a poorly differentiated human gastric cancer

T Tsuchiya  1 , Y Ueyama, N Tamaoki, S Yamaguchi, M Shibuya
Affiliations

Co-amplification of c-myc and c-erbB-2 oncogenes in a poorly differentiated human gastric cancer

T Tsuchiya et al. Jpn J Cancer Res. 1989 Oct.

Abstract

c-erbB-2 oncogene has been reported to be frequently amplified in differentiated, tubular type of gastric cancer. Here we report a human gastric cancer which bore co-amplified c-myc and c-erbB-2 oncogenes: a portion of the amplified c-erbB-2 oncogene was found to be rearranged. Furthermore, c-myc and c-erbB-2 oncogenes were over-expressed in the tumor cells. In contrast to the previous reports, this gastric adenocarcinoma was classified as a poorly differentiated type, and was highly tumorigenic in nude mice. These results might suggest that activated c-myc and c-erbB-2 oncogenes co-operate and influence the malignant state of some gastric carcinomas.

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