Clinical trials of stereotactic ablative radiotherapy for prostate cancer: updates and future direction
- PMID: 25757684
- DOI: 10.2217/fon.15.14
Clinical trials of stereotactic ablative radiotherapy for prostate cancer: updates and future direction
Abstract
Stereotactic body radiotherapy, also known as stereotactic ablative body radiotherapy (SABR), is an emerging treatment option for lung, prostate, liver and other tumors. Key factors in SABR are delivery of a high-dose radiation per fraction, proper patient positioning and target localization. Our review details the various radiotherapy techniques, dose fractionation schedules and toxicities for prostate SABR. Ongoing Phase II/III SABR studies across various risk groups have been included. It also discusses the role of conscientious focal dose escalation of the dominant intraprostatic nodule, integrating multiparametric MRI into radiotherapy protocols and finally cost-effectiveness of SABR.
Keywords: image-guided radiotherapy; prostate cancer; quality of life; stereotactic ablative radiotherapy.
Similar articles
-
Functional imaging guided stereotactic ablative body radiotherapy (SABR) with focal dose escalation and bladder trigone sparing for intermediate and high-risk prostate cancer: study protocol for phase II safo trial.Radiat Oncol. 2024 May 3;19(1):54. doi: 10.1186/s13014-024-02440-7. Radiat Oncol. 2024. PMID: 38702761 Free PMC article.
-
Stereotactic ablative body radiotherapy for lung cancer.Clin Oncol (R Coll Radiol). 2015 May;27(5):280-9. doi: 10.1016/j.clon.2015.01.006. Epub 2015 Mar 4. Clin Oncol (R Coll Radiol). 2015. PMID: 25746732
-
[Prostate cancer: what treatment techniques for which tumors? Ethical and methodological issues].Cancer Radiother. 2014 Oct;18(5-6):369-78. doi: 10.1016/j.canrad.2014.07.154. Epub 2014 Sep 6. Cancer Radiother. 2014. PMID: 25199865 Review. French.
-
Targeting Oligometastasis with Stereotactic Ablative Radiation Therapy or Surgery in Metastatic Hormone-sensitive Prostate Cancer: A Systematic Review of Prospective Clinical Trials.Eur Urol Oncol. 2020 Oct;3(5):582-593. doi: 10.1016/j.euo.2020.07.004. Epub 2020 Sep 3. Eur Urol Oncol. 2020. PMID: 32891600
-
Stereotactic body radiation therapy (stereotactic ablative radiotherapy) for stage I non-small cell lung cancer--updates of radiobiology, techniques, and clinical outcomes.Discov Med. 2010 May;9(48):411-7. Discov Med. 2010. PMID: 20515609 Review.
Cited by
-
Validation of a Quality Metric Score to Assess the Placement of Hydrogel Rectal Spacer in Patients Treated With Prostate Stereotactic Radiation Therapy.Adv Radiat Oncol. 2024 Jan 19;9(3):101396. doi: 10.1016/j.adro.2023.101396. eCollection 2024 Mar. Adv Radiat Oncol. 2024. PMID: 38304109 Free PMC article.
-
Big Data Analytics for Prostate Radiotherapy.Front Oncol. 2016 Jun 14;6:149. doi: 10.3389/fonc.2016.00149. eCollection 2016. Front Oncol. 2016. PMID: 27379211 Free PMC article. Review.
-
A review of the development of tumor vasculature and its effects on the tumor microenvironment.Hypoxia (Auckl). 2017 Apr 11;5:21-32. doi: 10.2147/HP.S133231. eCollection 2017. Hypoxia (Auckl). 2017. PMID: 28443291 Free PMC article. Review.
-
Stereotactic ablative body radiotherapy in patients with prostate cancer.Transl Androl Urol. 2018 Jun;7(3):330-340. doi: 10.21037/tau.2018.01.18. Transl Androl Urol. 2018. PMID: 30050794 Free PMC article. Review.
-
UK & Ireland Prostate Brachytherapy Practice Survey 2014-2016.J Contemp Brachytherapy. 2018 Jun;10(3):238-245. doi: 10.5114/jcb.2018.76839. Epub 2018 Jun 29. J Contemp Brachytherapy. 2018. PMID: 30038644 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
