Skeletal stem cells

doi:10.1242/dev.102210

Review

. 2015 Mar 15;142(6):1023-7.

doi: 10.1242/dev.102210.

Skeletal stem cells

Paolo Bianco¹, Pamela G Robey²

Affiliations

¹ Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy paolo.bianco@uniroma1.it probey@dir.nidcr.nih.gov.
² Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA paolo.bianco@uniroma1.it probey@dir.nidcr.nih.gov.

PMID: 25758217
PMCID: PMC4360182
DOI: 10.1242/dev.102210

Review

Skeletal stem cells

Paolo Bianco et al. Development. 2015.

. 2015 Mar 15;142(6):1023-7.

doi: 10.1242/dev.102210.

Authors

Paolo Bianco¹, Pamela G Robey²

Affiliations

¹ Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy paolo.bianco@uniroma1.it probey@dir.nidcr.nih.gov.
² Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA paolo.bianco@uniroma1.it probey@dir.nidcr.nih.gov.

PMID: 25758217
PMCID: PMC4360182
DOI: 10.1242/dev.102210

Abstract

Skeletal stem cells (SSCs) reside in the postnatal bone marrow and give rise to cartilage, bone, hematopoiesis-supportive stroma and marrow adipocytes in defined in vivo assays. These lineages emerge in a specific sequence during embryonic development and post natal growth, and together comprise a continuous anatomical system, the bone-bone marrow organ. SSCs conjoin skeletal and hematopoietic physiology, and are a tool for understanding and ameliorating skeletal and hematopoietic disorders. Here and in the accompanying poster, we concisely discuss the biology of SSCs in the context of the development and postnatal physiology of skeletal lineages, to which their use in medicine must remain anchored.

Keywords: Bone; Bone marrow stromal cell; Cartilage; Hematopoiesis; In vivo transplantation; Skeletal stem cells.

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References

1. Abdallah B. M. and Kassem M. (2012). New factors controlling the balance between osteoblastogenesis and adipogenesis. Bone 50, 540-545 10.1016/j.bone.2011.06.030 - DOI - PubMed
1. Arai F., Ohneda O., Miyamoto T., Zhang X. Q. and Suda T. (2002). Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J. Exp. Med. 195, 1549-1563 10.1084/jem.20011700 - DOI - PMC - PubMed
1. Beresford J. N., Bennett J. H., Devlin C., Leboy P. S. and Owen M. E. (1992). Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J. Cell Sci. 102, 341-351. - PubMed
1. Bi W., Deng J. M., Zhang Z., Behringer R. R. and de Crombrugghe B. (1999). Sox9 is required for cartilage formation. Nat. Genet. 22, 85-89 10.1038/8792 - DOI - PubMed
1. Bianco P. (2011). Bone and the hematopoietic niche: a tale of two stem cells. Blood 117, 5281-5288 10.1182/blood-2011-01-315069 - DOI - PubMed

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[1] Abdallah B. M. and Kassem M. (2012). New factors controlling the balance between osteoblastogenesis and adipogenesis. Bone 50, 540-545 10.1016/j.bone.2011.06.030 - DOI - PubMed

[2] Abdallah B. M. and Kassem M. (2012). New factors controlling the balance between osteoblastogenesis and adipogenesis. Bone 50, 540-545 10.1016/j.bone.2011.06.030 - DOI - PubMed

[3] Arai F., Ohneda O., Miyamoto T., Zhang X. Q. and Suda T. (2002). Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J. Exp. Med. 195, 1549-1563 10.1084/jem.20011700 - DOI - PMC - PubMed

[4] Arai F., Ohneda O., Miyamoto T., Zhang X. Q. and Suda T. (2002). Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation. J. Exp. Med. 195, 1549-1563 10.1084/jem.20011700 - DOI - PMC - PubMed

[5] Beresford J. N., Bennett J. H., Devlin C., Leboy P. S. and Owen M. E. (1992). Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J. Cell Sci. 102, 341-351. - PubMed

[6] Beresford J. N., Bennett J. H., Devlin C., Leboy P. S. and Owen M. E. (1992). Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J. Cell Sci. 102, 341-351. - PubMed

[7] Bi W., Deng J. M., Zhang Z., Behringer R. R. and de Crombrugghe B. (1999). Sox9 is required for cartilage formation. Nat. Genet. 22, 85-89 10.1038/8792 - DOI - PubMed

[8] Bi W., Deng J. M., Zhang Z., Behringer R. R. and de Crombrugghe B. (1999). Sox9 is required for cartilage formation. Nat. Genet. 22, 85-89 10.1038/8792 - DOI - PubMed

[9] Bianco P. (2011). Bone and the hematopoietic niche: a tale of two stem cells. Blood 117, 5281-5288 10.1182/blood-2011-01-315069 - DOI - PubMed

[10] Bianco P. (2011). Bone and the hematopoietic niche: a tale of two stem cells. Blood 117, 5281-5288 10.1182/blood-2011-01-315069 - DOI - PubMed

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Skeletal stem cells

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Skeletal stem cells

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