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Meta-Analysis
. 2015 Aug;473(8):2521-9.
doi: 10.1007/s11999-015-4227-8.

Do Complication Rates Differ by Gender After Metal-on-metal Hip Resurfacing Arthroplasty? A Systematic Review

Bryan D Haughom  1 , Brandon J Erickson, Michael D Hellman, Joshua J Jacobs
Affiliations
Meta-Analysis

Do Complication Rates Differ by Gender After Metal-on-metal Hip Resurfacing Arthroplasty? A Systematic Review

Bryan D Haughom et al. Clin Orthop Relat Res. 2015 Aug.

Abstract

Background: Although metal-on-metal (MoM) bearing surfaces provide low rates of volumetric wear and increased stability, evidence suggests that certain MoM hip arthroplasties have high rates of complication and failure. Some evidence indicates that women have higher rates of failure compared with men; however, the orthopaedic literature as a whole has poorly reported such complications stratified by gender.

Questions/purposes: This systematic review aimed to: (1) compare the rate of adverse local tissue reaction (ALTR); (2) dislocation; (3) aseptic loosening; and (4) revision between men and women undergoing primary MoM hip resurfacing arthroplasty (HRA).

Methods: Systematic MEDLINE and EMBASE searches identified all level I to III articles published in peer-reviewed journals, reporting on the outcomes of interest, for MoM HRA. Articles were limited to those with 2-year followup that reported outcomes by gender. Ten articles met inclusion criteria. Study quality was evaluated using the Modified Coleman Methodology Score; the overall quality was poor. Heterogeneity and bias were analyzed using a Mantel-Haenszel statistical method.

Results: Women demonstrated an increased odds of developing ALTR (odds ratio [OR], 5.70 [2.71-11.98]; p<0.001), dislocation (OR, 3.04 [1.2-7.5], p=0.02), aseptic loosening (OR, 3.18 [2.21-4.58], p<0.001), and revision (OR, 2.50 [2.25-2.78], p<0.001) after primary MoM HRA.

Conclusions: A systematic review of the currently available literature reveals a higher rate of complications (ALTR, dislocation, aseptic loosening, and revision) after MoM HRA in women compared with men. Although femoral head size has been frequently implicated as a prime factor in the higher rate of complication in women, further research is necessary to specifically probe this relationship. Retrospective studies of data available (eg, registry data) should be undertaken, and moving forward studies should report outcomes by gender (particularly complications).

Level of evidence: Level III, therapeutic study.

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Figures

Fig. 1
Fig. 1
Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) flowchart demonstrates the search strategy for our systematic review of gender differences in MoM HRA.
Fig. 2
Fig. 2
Gender differences in ALTR after MoM HRA are shown.
Fig. 3
Fig. 3
Gender differences in dislocation after MoM HRA are shown.
Fig. 4
Fig. 4
Gender differences in aseptic loosening after MoM HRA are shown.
Fig. 5
Fig. 5
Gender differences in revision after MoM HRA are shown.
See this image and copyright information in PMC

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