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. 2015 Apr 16;125(16):2579-81.
doi: 10.1182/blood-2014-10-606939. Epub 2015 Mar 10.

Prognostic value of FDG-PET prior to autologous stem cell transplantation for relapsed and refractory diffuse large B-cell lymphoma

Craig S Sauter  1 , Matthew J Matasar  1 , Jessica Meikle  2 , Heiko Schoder  3 , Gary A Ulaner  3 , Jocelyn C Migliacci  2 , Patrick Hilden  4 , Sean M Devlin  4 , Andrew D Zelenetz  1 , Craig H Moskowitz  1
Affiliations

Prognostic value of FDG-PET prior to autologous stem cell transplantation for relapsed and refractory diffuse large B-cell lymphoma

Craig S Sauter et al. Blood. .

Abstract

High-dose chemotherapy (HDT) plus autologous stem cell transplantation (ASCT) is the standard of care for chemosensitive relapsed and refractory diffuse large B-cell lymphoma (rel/ref DLBCL). Interim restaging with functional imaging by positron emission tomography using (18)F-deoxyglucose (FDG-PET) has not been established after salvage chemotherapy (ST) and before HDT-ASCT by modern criteria. Herein, we evaluated 129 patients with rel/ref DLBCL proceeding to HDT-ASCT, with ST response assessment by FDG-PET according to the contemporary Deauville 5-point scale. At 3 years, patients achieving a Deauville response of 1 to 3 to ST experienced superior progression-free survival (PFS) and overall survival (OS) rates of 77% and 86%, respectively, compared with patients achieving Deauville 4 (49% and 54%, respectively) (P < .001). No other pre-HDT-ASCT risk factors significantly impacted PFS or OS. Despite achieving remission to ST, patients with Deauville 4 should be the focus of risk-adapted investigational therapies.

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Figure 1
Figure 1
Kaplan-Meier survival estimates based on Deauville responses to ST. (A) PFS. (B) OS.
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