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Comment
. 2015 Mar 9;27(3):323-5.
doi: 10.1016/j.ccell.2015.02.013.

IDH1/2 mutations and BCL-2 dependence: an unexpected Chink in AML's armour

Elodie Pronier  1 , Ross L Levine  2
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Comment

IDH1/2 mutations and BCL-2 dependence: an unexpected Chink in AML's armour

Elodie Pronier et al. Cancer Cell. .
Free article

Abstract

There is a pressing need to develop novel, mechanism-based therapeutic approaches that can be used to improve therapies for genetically defined tumor subtypes. Chan and colleagues have demonstrated recently that BCL-2 inhibitors can target IDH1/2 mutant cancers through a mutant-specific dependency in metabolic regulation.

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