Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jun:103:27-32.
doi: 10.1016/j.fitote.2015.03.003. Epub 2015 Mar 7.

Five new benzylphenanthrenes from Cremastra appendiculata

Liang Liu  1 , Jun Li  2 , Ke-Wu Zeng  3 , Yong Jiang  3 , Peng-Fei Tu  4
Affiliations

Five new benzylphenanthrenes from Cremastra appendiculata

Liang Liu et al. Fitoterapia. 2015 Jun.

Abstract

Five new benzylphenanthrenes, cremaphenanthrenes L-P (1-5) were isolated from the EtOAc-soluble extract of the tubers of Cremastra appendiculata. Their structures were elucidated based on the spectroscopic data and chemical methods. Compounds 1-5 were tested in vitro for their cytotoxic effects against colon (HCT-116), cervix (Hela), and breast (MCF-7 and MDA-MB-231) cancer cell lines. Compound 1 showed moderate cytotoxic activities against HCT-116, MCF-7, and MDA-MB-231 cancer cell lines with IC50 values ranging from 15.84 to 24.18 μM and weak cytotoxicity to Hela cell line with IC50 value of 68.81 μM.

Keywords: Benzylphenanthrene; Cremastra appendiculata; Cytotoxic activity.

PubMed Disclaimer

Publication types

LinkOut - more resources