Treatment of early stage non-small cell lung cancer: surgery or stereotactic ablative radiotherapy?
- PMID: 25759766
- PMCID: PMC4342143
- DOI: 10.5152/balkanmedj.2015.15553
Treatment of early stage non-small cell lung cancer: surgery or stereotactic ablative radiotherapy?
Abstract
The management of early-stage Non-small Cell Lung Cancer (NSCLC) has improved recently due to advances in surgical and radiation modalities. Minimally-invasive procedures like Video-assisted thoracoscopic surgery (VATS) lobectomy decreases the morbidity of surgery, while the numerous methods of staging the mediastinum such as endobronchial and endoscopic ultrasound-guided biopsies are helping to achieve the objectives much more effectively. Stereotactic Ablative Radiotherapy (SABR) has become the frontrunner as the standard of care in medically inoperable early stage NSCLC patients, and has also been branded as tolerable and highly effective. Ongoing researches using SABR are continuously validating the optimal dosing and fractionation schemes, while at the same time instituting its role for both inoperable and operable patients.
Keywords: Central lung tumour; SABR; SBRT; Surgery; peripheral lung tumour.
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References
-
- Goldstraw P, Crowley J, Chansky K, Giroux DJ, Groome PA, Rami-Porta R, et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol. 2007;2:706–14. - PubMed
-
- Scott WJ, Howington J, Feigenberg S, Movsas B, Pisters K, American College of Chest Physicians Treatment of non-small cell lung cancer stage I and stage II: ACCP evidence-based clinical practice guidelines (2nd edition) Chest. 2007;132:234S–42S. - PubMed
-
- Colice GL, Shafazand S, Griffin JP, Keenan R, Bolliger CT, American College of Chest Physicians Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: ACCP evidenced-based clinical practice guidelines (2nd edition) Chest. 2007;132:161S–77S. - PubMed
-
- Puri V, Meyers BF. Optimal initial pathologic mediastinal staging of lung cancer: EUS, EBUS, mediastinoscopy. In: Ferguson MK, editor. Difficult decisions in thoracic surgery. London: Springer; 2011. pp. 67–75.
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